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Macrophage-associated wound healing contributes to African green monkey SIV pathogenesis control

Author

Listed:
  • Fredrik Barrenas

    (University of Washington
    Uppsala University)

  • Kevin Raehtz

    (University of Pittsburgh
    University of Pittsburgh)

  • Cuiling Xu

    (University of Pittsburgh)

  • Lynn Law

    (University of Washington
    University of Washington)

  • Richard R. Green

    (University of Washington
    University of Washington)

  • Guido Silvestri

    (Emory University
    Emory University)

  • Steven E. Bosinger

    (Emory University
    Emory University)

  • Andrew Nishida

    (University of Washington)

  • Qingsheng Li

    (University of Nebraska-Lincoln)

  • Wuxun Lu

    (University of Nebraska-Lincoln)

  • Jianshui Zhang

    (University of Nebraska-Lincoln)

  • Matthew J. Thomas

    (University of Washington
    University of Washington)

  • Jean Chang

    (University of Washington
    University of Washington)

  • Elise Smith

    (University of Washington
    University of Washington)

  • Jeffrey M. Weiss

    (University of Washington)

  • Reem A. Dawoud

    (Emory University)

  • George H. Richter

    (University of Pittsburgh)

  • Anita Trichel

    (University of Pittsburgh)

  • Dongzhu Ma

    (University of Pittsburgh)

  • Xinxia Peng

    (North Carolina State University)

  • Jan Komorowski

    (Uppsala University
    Institute of Computer Science, PAN)

  • Cristian Apetrei

    (University of Pittsburgh
    University of Pittsburgh)

  • Ivona Pandrea

    (University of Pittsburgh
    University of Pittsburgh)

  • Michael Gale

    (University of Washington
    University of Washington
    University of Washington)

Abstract

Natural hosts of simian immunodeficiency virus (SIV) avoid AIDS despite lifelong infection. Here, we examined how this outcome is achieved by comparing a natural SIV host, African green monkey (AGM) to an AIDS susceptible species, rhesus macaque (RM). To asses gene expression profiles from acutely SIV infected AGMs and RMs, we developed a systems biology approach termed Conserved Gene Signature Analysis (CGSA), which compared RNA sequencing data from rectal AGM and RM tissues to various other species. We found that AGMs rapidly activate, and then maintain, evolutionarily conserved regenerative wound healing mechanisms in mucosal tissue. The wound healing protein fibronectin shows distinct tissue distribution and abundance kinetics in AGMs. Furthermore, AGM monocytes exhibit an embryonic development and repair/regeneration signature featuring TGF-β and concomitant reduced expression of inflammatory genes compared to RMs. This regenerative wound healing process likely preserves mucosal integrity and prevents inflammatory insults that underlie immune exhaustion in RMs.

Suggested Citation

  • Fredrik Barrenas & Kevin Raehtz & Cuiling Xu & Lynn Law & Richard R. Green & Guido Silvestri & Steven E. Bosinger & Andrew Nishida & Qingsheng Li & Wuxun Lu & Jianshui Zhang & Matthew J. Thomas & Jean, 2019. "Macrophage-associated wound healing contributes to African green monkey SIV pathogenesis control," Nature Communications, Nature, vol. 10(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12987-9
    DOI: 10.1038/s41467-019-12987-9
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    Cited by:

    1. Quentin Le Hingrat & Paola Sette & Cuiling Xu & Andrew R. Rahmberg & Lilas Tarnus & Haritha Annapureddy & Adam Kleinman & Egidio Brocca-Cofano & Ranjit Sivanandham & Sindhuja Sivanandham & Tianyu He &, 2023. "Prolonged experimental CD4+ T-cell depletion does not cause disease progression in SIV-infected African green monkeys," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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