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In vivo engineered extracellular matrix scaffolds with instructive niches for oriented tissue regeneration

Author

Listed:
  • Meifeng Zhu

    (Nankai University
    Stevens Institute of Technology
    Tianjin Medical University)

  • Wen Li

    (Nankai University)

  • Xianhao Dong

    (Nankai University)

  • Xingyu Yuan

    (Nankai University)

  • Adam C. Midgley

    (Nankai University)

  • Hong Chang

    (Nankai University)

  • Yuhao Wang

    (Stevens Institute of Technology)

  • Haoyu Wang

    (Stevens Institute of Technology)

  • Kai Wang

    (Nankai University)

  • Peter X. Ma

    (University of Michigan)

  • Hongjun Wang

    (Stevens Institute of Technology)

  • Deling Kong

    (Nankai University
    Tianjin Medical University)

Abstract

Implanted scaffolds with inductive niches can facilitate the recruitment and differentiation of host cells, thereby enhancing endogenous tissue regeneration. Extracellular matrix (ECM) scaffolds derived from cultured cells or natural tissues exhibit superior biocompatibility and trigger favourable immune responses. However, the lack of hierarchical porous structure fails to provide cells with guidance cues for directional migration and spatial organization, and consequently limit the morpho-functional integration for oriented tissues. Here, we engineer ECM scaffolds with parallel microchannels (ECM-C) by subcutaneous implantation of sacrificial templates, followed by template removal and decellularization. The advantages of such ECM-C scaffolds are evidenced by close regulation of in vitro cell activities, and enhanced cell infiltration and vascularization upon in vivo implantation. We demonstrate the versatility and flexibility of these scaffolds by regenerating vascularized and innervated neo-muscle, vascularized neo-nerve and pulsatile neo-artery with functional integration. This strategy has potential to yield inducible biomaterials with applications across tissue engineering and regenerative medicine.

Suggested Citation

  • Meifeng Zhu & Wen Li & Xianhao Dong & Xingyu Yuan & Adam C. Midgley & Hong Chang & Yuhao Wang & Haoyu Wang & Kai Wang & Peter X. Ma & Hongjun Wang & Deling Kong, 2019. "In vivo engineered extracellular matrix scaffolds with instructive niches for oriented tissue regeneration," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12545-3
    DOI: 10.1038/s41467-019-12545-3
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    Cited by:

    1. Yi Li & Siyang Liu & Jingjing Zhang & Yumeng Wang & Hongjiang Lu & Yuexi Zhang & Guangzhou Song & Fanhua Niu & Yufan Shen & Adam C. Midgley & Wen Li & Deling Kong & Meifeng Zhu, 2024. "Elastic porous microspheres/extracellular matrix hydrogel injectable composites releasing dual bio-factors enable tissue regeneration," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

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