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Distinct transcriptional roles for Histone H3-K56 acetylation during the cell cycle in Yeast

Author

Listed:
  • Salih Topal

    (University of Massachusetts Medical School)

  • Pauline Vasseur

    (Institut de Génétique Moléculaire de Montpellier
    Université de Montpellier)

  • Marta Radman-Livaja

    (Institut de Génétique Moléculaire de Montpellier
    Université de Montpellier)

  • Craig L. Peterson

    (University of Massachusetts Medical School)

Abstract

Dynamic disruption and reassembly of promoter-proximal nucleosomes is a conserved hallmark of transcriptionally active chromatin. Histone H3-K56 acetylation (H3K56Ac) enhances these turnover events and promotes nucleosome assembly during S phase. Here we sequence nascent transcripts to investigate the impact of H3K56Ac on transcription throughout the yeast cell cycle. We find that H3K56Ac is a genome-wide activator of transcription. While H3K56Ac has a major impact on transcription initiation, it also appears to promote elongation and/or termination. In contrast, H3K56Ac represses promiscuous transcription that occurs immediately following replication fork passage, in this case by promoting efficient nucleosome assembly. We also detect a stepwise increase in transcription as cells transit S phase and enter G2, but this response to increased gene dosage does not require H3K56Ac. Thus, a single histone mark can exert both positive and negative impacts on transcription that are coupled to different cell cycle events.

Suggested Citation

  • Salih Topal & Pauline Vasseur & Marta Radman-Livaja & Craig L. Peterson, 2019. "Distinct transcriptional roles for Histone H3-K56 acetylation during the cell cycle in Yeast," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12400-5
    DOI: 10.1038/s41467-019-12400-5
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    Cited by:

    1. Lidice González & Daniel Kolbin & Christian Trahan & Célia Jeronimo & François Robert & Marlene Oeffinger & Kerry Bloom & Stephen W. Michnick, 2023. "Adaptive partitioning of a gene locus to the nuclear envelope in Saccharomyces cerevisiae is driven by polymer-polymer phase separation," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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