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Perioperative use of renin-angiotensin system inhibitors and outcomes in patients undergoing cardiac surgery

Author

Listed:
  • Qian Ding

    (Thomas Jefferson University
    Tangdu Hospital)

  • Zugui Zhang

    (Christiana Care Health System)

  • Hong Liu

    (University of California Davis Medical Center)

  • Huang Nie

    (Thomas Jefferson University
    Xijing Hospital)

  • Mark Berguson

    (Thomas Jefferson University)

  • Jordan E. Goldhammer

    (Thomas Jefferson University)

  • Nilas Young

    (University of California Davis Medical Center)

  • Douglas Boyd

    (University of California Davis Medical Center)

  • Rohinton Morris

    (Thomas Jefferson University)

  • Jianzhong Sun

    (Thomas Jefferson University)

Abstract

It remains disputable about perioperative use of renin-angiotensin system inhibitors (RASi) and their outcome effects. This multicenter retrospective cohort study examines association between use of perioperative RASi and outcomes in patients undergoing coronary artery bypass graft and/or valve surgery. After the exclusion, the patients are divided into 2 groups with or without preoperative RASi (PreRASi, n = 8581), or 2 groups with or without postoperative RASi (PostRASi, n = 8130). With using of propensity scores matching to reduce treatment selection bias, the study shows that PreRASi is associated with a significant reduction in postoperative 30-day mortality compared with without one (3.41% vs. 5.02%); PostRASi is associated with reduced long-term mortality rate compared with without one (6.62% vs. 7.70% at 2-year; 17.09% vs. 19.95% at 6-year). The results suggest that perioperative use of RASi has a significant benefit for the postoperative and long-term survival among patients undergoing cardiac surgery.

Suggested Citation

  • Qian Ding & Zugui Zhang & Hong Liu & Huang Nie & Mark Berguson & Jordan E. Goldhammer & Nilas Young & Douglas Boyd & Rohinton Morris & Jianzhong Sun, 2019. "Perioperative use of renin-angiotensin system inhibitors and outcomes in patients undergoing cardiac surgery," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11678-9
    DOI: 10.1038/s41467-019-11678-9
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