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Population dynamics of an Escherichia coli ST131 lineage during recurrent urinary tract infection

Author

Listed:
  • Brian M. Forde

    (The University of Queensland
    The University of Queensland
    The University of Queensland)

  • Leah W. Roberts

    (The University of Queensland
    The University of Queensland
    The University of Queensland)

  • Minh-Duy Phan

    (The University of Queensland
    The University of Queensland)

  • Kate M. Peters

    (The University of Queensland
    The University of Queensland)

  • Brittany A. Fleming

    (University of Utah School of Medicine)

  • Colin W. Russell

    (University of Utah School of Medicine)

  • Sara M. Lenherr

    (University of Utah)

  • Jeremy B. Myers

    (University of Utah)

  • Adam P. Barker

    (University of Utah)

  • Mark A. Fisher

    (University of Utah)

  • Teik-Min Chong

    (University of Malaya)

  • Wai-Fong Yin

    (University of Malaya)

  • Kok-Gan Chan

    (University of Malaya
    Jiangsu University)

  • Mark A. Schembri

    (The University of Queensland
    The University of Queensland)

  • Matthew A. Mulvey

    (University of Utah School of Medicine)

  • Scott A. Beatson

    (The University of Queensland
    The University of Queensland
    The University of Queensland)

Abstract

Recurrent urinary tract infections (rUTIs) are extremely common, with ~ 25% of all women experiencing a recurrence within 1 year of their original infection. Escherichia coli ST131 is a globally dominant multidrug resistant clone associated with high rates of rUTI. Here, we show the dynamics of an ST131 population over a 5-year period from one elderly woman with rUTI since the 1970s. Using whole genome sequencing, we identify an indigenous clonal lineage (P1A) linked to rUTI and persistence in the fecal flora, providing compelling evidence of an intestinal reservoir of rUTI. We also show that the P1A lineage possesses substantial plasmid diversity, resulting in the coexistence of antibiotic resistant and sensitive intestinal isolates despite frequent treatment. Our longitudinal study provides a unique comprehensive genomic analysis of a clonal lineage within a single individual and suggests a population-wide resistance mechanism enabling rapid adaptation to fluctuating antibiotic exposure.

Suggested Citation

  • Brian M. Forde & Leah W. Roberts & Minh-Duy Phan & Kate M. Peters & Brittany A. Fleming & Colin W. Russell & Sara M. Lenherr & Jeremy B. Myers & Adam P. Barker & Mark A. Fisher & Teik-Min Chong & Wai-, 2019. "Population dynamics of an Escherichia coli ST131 lineage during recurrent urinary tract infection," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11571-5
    DOI: 10.1038/s41467-019-11571-5
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    Cited by:

    1. Rhys T. White & Matthew J. Bull & Clare R. Barker & Julie M. Arnott & Mandy Wootton & Lim S. Jones & Robin A. Howe & Mari Morgan & Melinda M. Ashcroft & Brian M. Forde & Thomas R. Connor & Scott A. Be, 2024. "Genomic epidemiology reveals geographical clustering of multidrug-resistant Escherichia coli ST131 associated with bacteraemia in Wales," Nature Communications, Nature, vol. 15(1), pages 1-10, December.

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