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MpsAB is important for Staphylococcus aureus virulence and growth at atmospheric CO2 levels

Author

Listed:
  • Sook-Ha Fan

    (University of Tübingen)

  • Patrick Ebner

    (University of Tübingen)

  • Sebastian Reichert

    (University of Tübingen)

  • Tobias Hertlein

    (University of Würzburg)

  • Susanne Zabel

    (University of Tübingen, Sand 14)

  • Aditya Kumar Lankapalli

    (Max Planck Institute for the Science of Human History)

  • Kay Nieselt

    (University of Tübingen, Sand 14)

  • Knut Ohlsen

    (University of Würzburg)

  • Friedrich Götz

    (University of Tübingen)

Abstract

The mechanisms behind carbon dioxide (CO2) dependency in non-autotrophic bacterial isolates are unclear. Here we show that the Staphylococcus aureus mpsAB operon, known to play a role in membrane potential generation, is crucial for growth at atmospheric CO2 levels. The genes mpsAB can complement an Escherichia coli carbonic anhydrase (CA) mutant, and CA from E. coli can complement the S. aureus delta-mpsABC mutant. In comparison with the wild type, S. aureus mps mutants produce less hemolytic toxin and are less virulent in animal models of infection. Homologs of mpsA and mpsB are widespread among bacteria and are often found adjacent to each other on the genome. We propose that MpsAB represents a dissolved inorganic carbon transporter, or bicarbonate concentrating system, possibly acting as a sodium bicarbonate cotransporter.

Suggested Citation

  • Sook-Ha Fan & Patrick Ebner & Sebastian Reichert & Tobias Hertlein & Susanne Zabel & Aditya Kumar Lankapalli & Kay Nieselt & Knut Ohlsen & Friedrich Götz, 2019. "MpsAB is important for Staphylococcus aureus virulence and growth at atmospheric CO2 levels," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11547-5
    DOI: 10.1038/s41467-019-11547-5
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