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Integrated TORC1 and PKA signaling control the temporal activation of glucose-induced gene expression in yeast

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  • Joseph Kunkel

    (University of Arizona)

  • Xiangxia Luo

    (University of Arizona)

  • Andrew P. Capaldi

    (University of Arizona)

Abstract

The growth rate of a yeast cell is controlled by the target of rapamycin kinase complex I (TORC1) and cAMP-dependent protein kinase (PKA) pathways. To determine how TORC1 and PKA cooperate to regulate cell growth, we performed temporal analysis of gene expression in yeast switched from a non-fermentable substrate, to glucose, in the presence and absence of TORC1 and PKA inhibitors. Quantitative analysis of these data reveals that PKA drives the expression of key cell growth genes during transitions into, and out of, the rapid growth state in glucose, while TORC1 is important for the steady-state expression of the same genes. This circuit design may enable yeast to set an exact growth rate based on the abundance of internal metabolites such as amino acids, via TORC1, but also adapt rapidly to changes in external nutrients, such as glucose, via PKA.

Suggested Citation

  • Joseph Kunkel & Xiangxia Luo & Andrew P. Capaldi, 2019. "Integrated TORC1 and PKA signaling control the temporal activation of glucose-induced gene expression in yeast," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11540-y
    DOI: 10.1038/s41467-019-11540-y
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    Cited by:

    1. Ibrahim E. Elsemman & Angelica Rodriguez Prado & Pranas Grigaitis & Manuel Garcia Albornoz & Victoria Harman & Stephen W. Holman & Johan Heerden & Frank J. Bruggeman & Mark M. M. Bisschops & Nikolaus , 2022. "Whole-cell modeling in yeast predicts compartment-specific proteome constraints that drive metabolic strategies," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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