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Target specific functions of EPL interneurons in olfactory circuits

Author

Listed:
  • Gary Liu

    (Baylor College of Medicine
    Baylor College of Medicine)

  • Emmanouil Froudarakis

    (Baylor College of Medicine
    Baylor College of Medicine)

  • Jay M. Patel

    (Baylor College of Medicine
    Baylor College of Medicine)

  • Mikhail Y. Kochukov

    (Baylor College of Medicine)

  • Brandon Pekarek

    (Baylor College of Medicine)

  • Patrick J. Hunt

    (Baylor College of Medicine
    Baylor College of Medicine)

  • Mayuri Patel

    (Baylor College of Medicine)

  • Kevin Ung

    (Baylor College of Medicine)

  • Chia-Hsuan Fu

    (Baylor College of Medicine)

  • Juyeong Jo

    (Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital
    Baylor College of Medicine)

  • Hyun-Kyoung Lee

    (Baylor College of Medicine
    Baylor College of Medicine
    Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital
    Baylor College of Medicine)

  • Andreas S. Tolias

    (Baylor College of Medicine
    Baylor College of Medicine
    Rice University)

  • Benjamin R. Arenkiel

    (Baylor College of Medicine
    Baylor College of Medicine
    Baylor College of Medicine
    Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital)

Abstract

Inhibitory interneurons are integral to sensory processing, yet revealing their cell type-specific roles in sensory circuits remains an ongoing focus. To Investigate the mouse olfactory system, we selectively remove GABAergic transmission from a subset of olfactory bulb interneurons, EPL interneurons (EPL-INs), and assay odor responses from their downstream synaptic partners — tufted cells and mitral cells. Using a combination of in vivo electrophysiological and imaging analyses, we find that inactivating this single node of inhibition leads to differential effects in magnitude, reliability, tuning width, and temporal dynamics between the two principal neurons. Furthermore, tufted and not mitral cell responses to odor mixtures become more linearly predictable without EPL-IN inhibition. Our data suggest that olfactory bulb interneurons, through exerting distinct inhibitory functions onto their different synaptic partners, play a significant role in the processing of odor information.

Suggested Citation

  • Gary Liu & Emmanouil Froudarakis & Jay M. Patel & Mikhail Y. Kochukov & Brandon Pekarek & Patrick J. Hunt & Mayuri Patel & Kevin Ung & Chia-Hsuan Fu & Juyeong Jo & Hyun-Kyoung Lee & Andreas S. Tolias , 2019. "Target specific functions of EPL interneurons in olfactory circuits," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11354-y
    DOI: 10.1038/s41467-019-11354-y
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