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Lateral dispersion is required for circuit integration of newly generated dentate granule cells

Author

Listed:
  • Jia Wang

    (SUNY at Stony Brook
    Peking University)

  • Jia Shen

    (SUNY at Stony Brook
    SUNY at Stony Brook)

  • Gregory W. Kirschen

    (SUNY at Stony Brook
    SUNY at Stony Brook)

  • Yan Gu

    (SUNY at Stony Brook
    Zhejiang University School of Medicine)

  • Sebastian Jessberger

    (University of Zurich)

  • Shaoyu Ge

    (SUNY at Stony Brook)

Abstract

The process of circuit integration of newly-generated dentate granule cells of the hippocampus has been presumed to be a dynamic process. In fact, little is known regarding the initial development of newly generated neurons prior to circuit integration and the significance of this stage for circuit integration. Here, using advanced live imaging methods, we systematically analyze the dynamic dispersion of newly generated neurons in the neurogenic zone and observe that cells that are physically adjacent coordinate their lateral dispersion. Whole-cell recordings of adjacent newly generated neurons reveal that they are coupled via gap junctions. The dispersion of newly generated cells in the neurogenic zone is restricted when this coupling is disrupted, which severely impairs their subsequent integration into the hippocampal circuit. The results of this study reveal that the dynamic dispersion of newly generated dentate granule cells in the neurogenic zone is a required developmental stage for circuit integration.

Suggested Citation

  • Jia Wang & Jia Shen & Gregory W. Kirschen & Yan Gu & Sebastian Jessberger & Shaoyu Ge, 2019. "Lateral dispersion is required for circuit integration of newly generated dentate granule cells," Nature Communications, Nature, vol. 10(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11206-9
    DOI: 10.1038/s41467-019-11206-9
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