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Use cases, best practice and reporting standards for metabolomics in regulatory toxicology

Author

Listed:
  • Mark R. Viant

    (University of Birmingham)

  • Timothy M. D. Ebbels

    (Imperial College London)

  • Richard D. Beger

    (NCTR)

  • Drew R. Ekman

    (US EPA)

  • David J. T. Epps

    (University of Birmingham)

  • Hennicke Kamp

    (BASF SE)

  • Pim E. G. Leonards

    (Vrije Universiteit Amsterdam)

  • George D. Loizou

    (Health and Safety Executive)

  • James I. MacRae

    (The Francis Crick Institute)

  • Bennard Ravenzwaay

    (BASF SE)

  • Philippe Rocca-Serra

    (University of Oxford)

  • Reza M. Salek

    (International Agency for Research on Cancer)

  • Tilmann Walk

    (BASF Metabolome Solutions)

  • Ralf J. M. Weber

    (University of Birmingham)

Abstract

Metabolomics is a widely used technology in academic research, yet its application to regulatory science has been limited. The most commonly cited barrier to its translation is lack of performance and reporting standards. The MEtabolomics standaRds Initiative in Toxicology (MERIT) project brings together international experts from multiple sectors to address this need. Here, we identify the most relevant applications for metabolomics in regulatory toxicology and develop best practice guidelines, performance and reporting standards for acquiring and analysing untargeted metabolomics and targeted metabolite data. We recommend that these guidelines are evaluated and implemented for several regulatory use cases.

Suggested Citation

  • Mark R. Viant & Timothy M. D. Ebbels & Richard D. Beger & Drew R. Ekman & David J. T. Epps & Hennicke Kamp & Pim E. G. Leonards & George D. Loizou & James I. MacRae & Bennard Ravenzwaay & Philippe Roc, 2019. "Use cases, best practice and reporting standards for metabolomics in regulatory toxicology," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10900-y
    DOI: 10.1038/s41467-019-10900-y
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    Cited by:

    1. Tara J. Bowen & Andrew D. Southam & Andrew R. Hall & Ralf J. M. Weber & Gavin R. Lloyd & Ruth Macdonald & Amanda Wilson & Amy Pointon & Mark R. Viant, 2023. "Simultaneously discovering the fate and biochemical effects of pharmaceuticals through untargeted metabolomics," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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