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Actomyosin-driven force patterning controls endocytosis at the immune synapse

Author

Listed:
  • Anita Kumari

    (PSL Research University, INSERM U932, 26 rue d’Ulm
    Université Paris Descartes)

  • Judith Pineau

    (PSL Research University, INSERM U932, 26 rue d’Ulm
    Université Paris Descartes)

  • Pablo J. Sáez

    (PSL Research University, INSERM U932, 26 rue d’Ulm)

  • Mathieu Maurin

    (PSL Research University, INSERM U932, 26 rue d’Ulm)

  • Danielle Lankar

    (PSL Research University, INSERM U932, 26 rue d’Ulm)

  • Mabel San Roman

    (PSL Research University, INSERM U932, 26 rue d’Ulm)

  • Katharina Hennig

    (Laboratoire Interdisciplinaire de Physique, Université Joseph Fourier (Grenoble 1))

  • Vanessa F. Boura

    (Tumor and Cell Biology, Karolinska Institutet)

  • Raphael Voituriez

    (UMR 7600 CNRS /UPMC and Laboratoire Jean Perrin, UMR 8237 CNRS /UPMC, 4 Place Jussieu)

  • Mikael C. I. Karlsson

    (Tumor and Cell Biology, Karolinska Institutet)

  • Martial Balland

    (Laboratoire Interdisciplinaire de Physique, Université Joseph Fourier (Grenoble 1))

  • Ana-Maria Lennon Dumenil

    (PSL Research University, INSERM U932, 26 rue d’Ulm)

  • Paolo Pierobon

    (PSL Research University, INSERM U932, 26 rue d’Ulm)

Abstract

An important channel of cell-to-cell communication is direct contact. The immune synapse is a paradigmatic example of such type of interaction: it forms upon engagement of antigen receptors in lymphocytes by antigen-presenting cells and allows the local exchange of molecules and information. Although mechanics has been shown to play an important role in this process, how forces organize and impact on synapse function is unknown. We find that mechanical forces are spatio-temporally patterned at the immune synapse: global pulsatile myosin II-driven tangential forces are observed at the synapse periphery while localised forces generated by invadosome-like F-actin protrusions are detected at its centre. Noticeably, we observe that these force-producing actin protrusions constitute the main site of antigen extraction and endocytosis and require myosin II contractility to form. The interplay between global and local forces dictated by the organization of the actomyosin cytoskeleton therefore controls endocytosis at the immune synapse.

Suggested Citation

  • Anita Kumari & Judith Pineau & Pablo J. Sáez & Mathieu Maurin & Danielle Lankar & Mabel San Roman & Katharina Hennig & Vanessa F. Boura & Raphael Voituriez & Mikael C. I. Karlsson & Martial Balland & , 2019. "Actomyosin-driven force patterning controls endocytosis at the immune synapse," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10751-7
    DOI: 10.1038/s41467-019-10751-7
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