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Loci for human leukocyte telomere length in the Singaporean Chinese population and trans-ethnic genetic studies

Author

Listed:
  • Rajkumar Dorajoo

    (Agency for Science, Technology and Research)

  • Xuling Chang

    (National University of Singapore
    National University Health System)

  • Resham Lal Gurung

    (Khoo Teck Puat Hospital)

  • Zheng Li

    (Agency for Science, Technology and Research)

  • Ling Wang

    (Agency for Science, Technology and Research)

  • Renwei Wang

    (University of Pittsburgh)

  • Kenneth B. Beckman

    (University of Minnesota)

  • Jennifer Adams-Haduch

    (University of Pittsburgh)

  • Yiamunaa M

    (Khoo Teck Puat Hospital)

  • Sylvia Liu

    (Khoo Teck Puat Hospital)

  • Wee Yang Meah

    (Agency for Science, Technology and Research)

  • Kar Seng Sim

    (Agency for Science, Technology and Research)

  • Su Chi Lim

    (Khoo Teck Puat Hospital
    Khoo Teck Puat Hospital
    National University of Singapore)

  • Yechiel Friedlander

    (Hebrew University of Jerusalem)

  • Jianjun Liu

    (Agency for Science, Technology and Research
    National University of Singapore)

  • Rob M. van Dam

    (National University of Singapore
    National University of Singapore)

  • Jian-Min Yuan

    (University of Pittsburgh
    University of Pittsburgh)

  • Woon-Puay Koh

    (National University of Singapore
    Duke-NUS Medical School Singapore)

  • Chiea Chuen Khor

    (Agency for Science, Technology and Research
    Singapore National Eye Centre)

  • Chew-Kiat Heng

    (National University of Singapore
    National University Health System)

Abstract

Genetic factors underlying leukocyte telomere length (LTL) may provide insights into telomere homeostasis, with direct links to disease susceptibility. Genetic evaluation of 23,096 Singaporean Chinese samples identifies 10 genome-wide loci (P

Suggested Citation

  • Rajkumar Dorajoo & Xuling Chang & Resham Lal Gurung & Zheng Li & Ling Wang & Renwei Wang & Kenneth B. Beckman & Jennifer Adams-Haduch & Yiamunaa M & Sylvia Liu & Wee Yang Meah & Kar Seng Sim & Su Chi , 2019. "Loci for human leukocyte telomere length in the Singaporean Chinese population and trans-ethnic genetic studies," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10443-2
    DOI: 10.1038/s41467-019-10443-2
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    Cited by:

    1. Rebecca Keener & Surya B. Chhetri & Carla J. Connelly & Margaret A. Taub & Matthew P. Conomos & Joshua Weinstock & Bohan Ni & Benjamin Strober & Stella Aslibekyan & Paul L. Auer & Lucas Barwick & Lewi, 2024. "Validation of human telomere length multi-ancestry meta-analysis association signals identifies POP5 and KBTBD6 as human telomere length regulation genes," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    2. Ying Chang & Yao Zhou & Junrui Zhou & Wen Li & Jiasong Cao & Yaqing Jing & Shan Zhang & Yongmei Shen & Qimei Lin & Xutong Fan & Hongxi Yang & Xiaobao Dong & Shijie Zhang & Xianfu Yi & Ling Shuai & Lei, 2023. "Unraveling the causal genes and transcriptomic determinants of human telomere length," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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