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Impaired cerebellar Purkinje cell potentiation generates unstable spatial map orientation and inaccurate navigation

Author

Listed:
  • Julie Marie Lefort

    (CeZaMe)

  • Jean Vincent

    (CeZaMe)

  • Lucille Tallot

    (CeZaMe)

  • Frédéric Jarlier

    (CeZaMe)

  • Chris Innocentius De Zeeuw

    (Royal Netherlands Academy of Arts and Sciences
    Erasmus MC)

  • Laure Rondi-Reig

    (CeZaMe)

  • Christelle Rochefort

    (CeZaMe)

Abstract

Cerebellar activity supported by PKC-dependent long-term depression in Purkinje cells (PCs) is involved in the stabilization of self-motion based hippocampal representation, but the existence of cerebellar processes underlying integration of allocentric cues remains unclear. Using mutant-mice lacking PP2B in PCs (L7-PP2B mice) we here assess the role of PP2B-dependent PC potentiation in hippocampal representation and spatial navigation. L7-PP2B mice display higher susceptibility to spatial map instability relative to the allocentric cue and impaired allocentric as well as self-motion goal-directed navigation. These results indicate that PP2B-dependent potentiation in PCs contributes to maintain a stable hippocampal representation of a familiar environment in an allocentric reference frame as well as to support optimal trajectory toward a goal during navigation.

Suggested Citation

  • Julie Marie Lefort & Jean Vincent & Lucille Tallot & Frédéric Jarlier & Chris Innocentius De Zeeuw & Laure Rondi-Reig & Christelle Rochefort, 2019. "Impaired cerebellar Purkinje cell potentiation generates unstable spatial map orientation and inaccurate navigation," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09958-5
    DOI: 10.1038/s41467-019-09958-5
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