IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v10y2019i1d10.1038_s41467-019-09865-9.html
   My bibliography  Save this article

RETRACTED ARTICLE: RNA m6A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail

Author

Listed:
  • Xinyao Lin

    (Sun Yat-sen University)

  • Guoshi Chai

    (Sun Yat-sen University)

  • Yingmin Wu

    (Sun Yat-sen University)

  • Jiexin Li

    (Sun Yat-sen University)

  • Feng Chen

    (Sun Yat-sen University)

  • Jianzhao Liu

    (The University of Chicago
    Zhejiang University)

  • Guanzheng Luo

    (Sun Yat-sen University
    The University of Chicago)

  • Jordi Tauler

    (The University of Chicago)

  • Jun Du

    (Sun Yat-sen University)

  • Shuibin Lin

    (Sun Yat-sen University)

  • Chuan He

    (The University of Chicago)

  • Hongsheng Wang

    (Sun Yat-sen University)

Abstract

N6-Methyladenosine (m6A) modification has been implicated in the progression of several cancers. We reveal that during epithelial-mesenchymal transition (EMT), one important step for cancer cell metastasis, m6A modification of mRNAs increases in cancer cells. Deletion of methyltransferase-like 3 (METTL3) down-regulates m6A, impairs the migration, invasion and EMT of cancer cells both in vitro and in vivo. m6A-sequencing and functional studies confirm that Snail, a key transcription factor of EMT, is involved in m6A-regulated EMT. m6A in Snail CDS, but not 3’UTR, triggers polysome-mediated translation of Snail mRNA in cancer cells. Loss and gain functional studies confirm that YTHDF1 mediates m6A-increased translation of Snail mRNA. Moreover, the upregulation of METTL3 and YTHDF1 act as adverse prognosis factors for overall survival (OS) rate of liver cancer patients. Our study highlights the critical roles of m6A on regulation of EMT in cancer cells and translation of Snail during this process.

Suggested Citation

  • Xinyao Lin & Guoshi Chai & Yingmin Wu & Jiexin Li & Feng Chen & Jianzhao Liu & Guanzheng Luo & Jordi Tauler & Jun Du & Shuibin Lin & Chuan He & Hongsheng Wang, 2019. "RETRACTED ARTICLE: RNA m6A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09865-9
    DOI: 10.1038/s41467-019-09865-9
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-019-09865-9
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-019-09865-9?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09865-9. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.