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Comprehensive genomic and immunological characterization of Chinese non-small cell lung cancer patients

Author

Listed:
  • Xu-Chao Zhang

    (Guangdong Provincial People’s Hospital and Guangdong Academy of Medical Sciences)

  • Jun Wang

    (Peking University People’s Hospital)

  • Guo-Guang Shao

    (1st Hospital of Jilin University)

  • Qun Wang

    (Zhongshan Hospital, Fudan University)

  • Xiaotao Qu

    (Janssen R&D China)

  • Bo Wang

    (Janssen R&D China)

  • Christopher Moy

    (Janssen R&D)

  • Yue Fan

    (Janssen R&D China)

  • Zayed Albertyn

    (Novocraft Technologies)

  • Xiayu Huang

    (Janssen R&D China)

  • Jingyu Zhang

    (Janssen R&D China)

  • Yang Qiu

    (Janssen R&D China)

  • Suso Platero

    (Janssen R&D)

  • Matthew V. Lorenzi

    (Janssen R&D)

  • Enrique Zudaire

    (Janssen R&D)

  • Jennifer Yang

    (Janssen R&D China)

  • Ying Cheng

    (Jilin Provincial Cancer Hospital)

  • Lin Xu

    (Cancer Institute of Jiangsu Province)

  • Yi-Long Wu

    (Guangdong Provincial People’s Hospital and Guangdong Academy of Medical Sciences)

Abstract

Deep understanding of the genomic and immunological differences between Chinese and Western lung cancer patients is of great importance for target therapy selection and development for Chinese patients. Here we report an extensive molecular and immune profiling study of 245 Chinese patients with non-small cell lung cancer. Tumor-infiltrating lymphocyte estimated using immune cell signatures is found to be significantly higher in adenocarcinoma (ADC, 72.5%) compared with squamous cell carcinoma (SQCC, 54.4%). The correlation of genomic alterations with immune signatures reveals that low immune infiltration was associated with EGFR mutations in ADC samples, PI3K and/or WNT pathway activation in SQCC. While KRAS mutations are found to be significantly associated with T cell infiltration in ADC samples. The SQCC patients with high antigen presentation machinery and cytotoxic T cell signature scores are found to have a prolonged overall survival time.

Suggested Citation

  • Xu-Chao Zhang & Jun Wang & Guo-Guang Shao & Qun Wang & Xiaotao Qu & Bo Wang & Christopher Moy & Yue Fan & Zayed Albertyn & Xiayu Huang & Jingyu Zhang & Yang Qiu & Suso Platero & Matthew V. Lorenzi & E, 2019. "Comprehensive genomic and immunological characterization of Chinese non-small cell lung cancer patients," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09762-1
    DOI: 10.1038/s41467-019-09762-1
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    Cited by:

    1. Bin Qiu & Wei Guo & Fan Zhang & Fang Lv & Ying Ji & Yue Peng & Xiaoxi Chen & Hua Bao & Yang Xu & Yang Shao & Fengwei Tan & Qi Xue & Shugeng Gao & Jie He, 2021. "Dynamic recurrence risk and adjuvant chemotherapy benefit prediction by ctDNA in resected NSCLC," Nature Communications, Nature, vol. 12(1), pages 1-11, December.

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