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Bridging the gap between transition metal- and bio-catalysis via aqueous micellar catalysis

Author

Listed:
  • Margery Cortes-Clerget

    (University of California)

  • Nnamdi Akporji

    (University of California)

  • Jianguang Zhou

    (Suzhou Novartis Pharma Technology Company Limited)

  • Feng Gao

    (Suzhou Novartis Pharma Technology Company Limited)

  • Pengfei Guo

    (Suzhou Novartis Pharma Technology Company Limited)

  • Michael Parmentier

    (Novartis Pharma AG)

  • Fabrice Gallou

    (Novartis Pharma AG)

  • Jean-Yves Berthon

    (Biopôle Clermont Limagne)

  • Bruce H. Lipshutz

    (University of California)

Abstract

Previous studies have shown that aqueous solutions of designer surfactants enable a wide variety of valuable transformations in synthetic organic chemistry. Since reactions take place within the inner hydrophobic cores of these tailor-made nanoreactors, and products made therein are in dynamic exchange between micelles through the water, opportunities exist to use enzymes to effect secondary processes. Herein we report that ketone-containing products, formed via initial transition metal-catalyzed reactions based on Pd, Cu, Rh, Fe and Au, can be followed in the same pot by enzymatic reductions mediated by alcohol dehydrogenases. Most noteworthy is the finding that nanomicelles present in the water appear to function not only as a medium for both chemo- and bio-catalysis, but as a reservoir for substrates, products, and catalysts, decreasing noncompetitive enzyme inhibition.

Suggested Citation

  • Margery Cortes-Clerget & Nnamdi Akporji & Jianguang Zhou & Feng Gao & Pengfei Guo & Michael Parmentier & Fabrice Gallou & Jean-Yves Berthon & Bruce H. Lipshutz, 2019. "Bridging the gap between transition metal- and bio-catalysis via aqueous micellar catalysis," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09751-4
    DOI: 10.1038/s41467-019-09751-4
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    Cited by:

    1. Xinzhe Tian & Yinggang Guo & Wankai An & Yun-Lai Ren & Yuchen Qin & Caoyuan Niu & Xin Zheng, 2022. "Coupling photocatalytic water oxidation with reductive transformations of organic molecules," Nature Communications, Nature, vol. 13(1), pages 1-10, December.

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