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Recollection in the human hippocampal-entorhinal cell circuitry

Author

Listed:
  • Bernhard P. Staresina

    (University of Birmingham
    University of Birmingham)

  • Thomas P. Reber

    (University of Bonn Medical Centre
    Swiss Distance Learning University)

  • Johannes Niediek

    (University of Bonn Medical Centre)

  • Jan Boström

    (University of Bonn Medical Centre)

  • Christian E. Elger

    (University of Bonn Medical Centre)

  • Florian Mormann

    (University of Bonn Medical Centre)

Abstract

Imagine how flicking through your photo album and seeing a picture of a beach sunset brings back fond memories of a tasty cocktail you had that night. Computational models suggest that upon receiving a partial memory cue (‘beach’), neurons in the hippocampus coordinate reinstatement of associated memories (‘cocktail’) in cortical target sites. Here, using human single neuron recordings, we show that hippocampal firing rates are elevated from ~ 500–1500 ms after cue onset during successful associative retrieval. Concurrently, the retrieved target object can be decoded from population spike patterns in adjacent entorhinal cortex (EC), with hippocampal firing preceding EC spikes and predicting the fidelity of EC object reinstatement. Prior to orchestrating reinstatement, a separate population of hippocampal neurons distinguishes different scene cues (buildings vs. landscapes). These results elucidate the hippocampal-entorhinal circuit dynamics for memory recall and reconcile disparate views on the role of the hippocampus in scene processing vs. associative memory.

Suggested Citation

  • Bernhard P. Staresina & Thomas P. Reber & Johannes Niediek & Jan Boström & Christian E. Elger & Florian Mormann, 2019. "Recollection in the human hippocampal-entorhinal cell circuitry," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09558-3
    DOI: 10.1038/s41467-019-09558-3
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    Cited by:

    1. Sanne Ten Oever & Alexander T. Sack & Carina R. Oehrn & Nikolai Axmacher, 2021. "An engram of intentionally forgotten information," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    2. Marcel Bausch & Johannes Niediek & Thomas P. Reber & Sina Mackay & Jan Boström & Christian E. Elger & Florian Mormann, 2021. "Concept neurons in the human medial temporal lobe flexibly represent abstract relations between concepts," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    3. Xiaxia Xu & Lingzhen Song & Rebecca Kringel & Ileana L. Hanganu-Opatz, 2021. "Developmental decrease of entorhinal-hippocampal communication in immune-challenged DISC1 knockdown mice," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    4. Fraser Aitken & Peter Kok, 2022. "Hippocampal representations switch from errors to predictions during acquisition of predictive associations," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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