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Perfluorocarbon regulates the intratumoural environment to enhance hypoxia-based agent efficacy

Author

Listed:
  • Wenguang Wang

    (Nanjing University
    Nanjing University)

  • Yuhao Cheng

    (Nanjing University
    Nanjing University)

  • Peng Yu

    (Nanjing University
    Nanjing University)

  • Haoran Wang

    (Nanjing University
    Nanjing University)

  • Yue Zhang

    (Nanjing University
    Nanjing University)

  • Haiheng Xu

    (Nanjing University
    Nanjing University)

  • Qingsong Ye

    (Nanjing University
    Nanjing University)

  • Ahu Yuan

    (Nanjing University
    Nanjing University)

  • Yiqiao Hu

    (Nanjing University
    Nanjing University
    Nanjing University)

  • Jinhui Wu

    (Nanjing University
    Nanjing University
    Nanjing University)

Abstract

Hypoxia-based agents (HBAs), such as anaerobic bacteria and bioreductive prodrugs, require both a permeable and hypoxic intratumoural environment to be fully effective. To solve this problem, herein, we report that perfluorocarbon nanoparticles (PNPs) can be used to create a long-lasting, penetrable and hypoxic tumour microenvironment for ensuring both the delivery and activation of subsequently administered HBAs. In addition to the increased permeability and enhanced hypoxia caused by the PNPs, the PNPs can be retained to further achieve the long-term inhibition of intratumoural O2 reperfusion while enhancing HBA accumulation for over 24 h. Therefore, perfluorocarbon materials may have great potential for reigniting clinical research on hypoxia-based drugs.

Suggested Citation

  • Wenguang Wang & Yuhao Cheng & Peng Yu & Haoran Wang & Yue Zhang & Haiheng Xu & Qingsong Ye & Ahu Yuan & Yiqiao Hu & Jinhui Wu, 2019. "Perfluorocarbon regulates the intratumoural environment to enhance hypoxia-based agent efficacy," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09389-2
    DOI: 10.1038/s41467-019-09389-2
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