IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v10y2019i1d10.1038_s41467-019-09028-w.html
   My bibliography  Save this article

Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis

Author

Listed:
  • Hiroyasu Kidoya

    (Osaka University)

  • Fumitaka Muramatsu

    (Osaka University)

  • Teppei Shimamura

    (Nagoya University)

  • Weizhen Jia

    (Osaka University)

  • Takashi Satoh

    (Osaka University)

  • Yumiko Hayashi

    (Osaka University)

  • Hisamichi Naito

    (Osaka University)

  • Yuya Kunisaki

    (Kyushu University)

  • Fumio Arai

    (Kyushu University)

  • Masahide Seki

    (The University of Tokyo)

  • Yutaka Suzuki

    (The University of Tokyo)

  • Tsuyoshi Osawa

    (The University of Tokyo)

  • Shizuo Akira

    (Osaka University
    Osaka University)

  • Nobuyuki Takakura

    (Osaka University)

Abstract

The balance between self-renewal and differentiation of hematopoietic stem and progenitor cells (HSPCs) maintains hematopoietic homeostasis, failure of which can lead to hematopoietic disorder. HSPC fate is controlled by signals from the bone marrow niche resulting in alteration of the stem cell transcription network. Regnase-1, a member of the CCCH zinc finger protein family possessing RNAse activity, mediates post-transcriptional regulatory activity through degradation of target mRNAs. The precise function of Regnase-1 has been explored in inflammation-related cytokine expression but its function in hematopoiesis has not been elucidated. Here, we show that Regnase-1 regulates self-renewal of HSPCs through modulating the stability of Gata2 and Tal1 mRNA. In addition, we found that dysfunction of Regnase-1 leads to the rapid onset of abnormal hematopoiesis. Thus, our data reveal that Regnase-1-mediated post-transcriptional regulation is required for HSPC maintenance and suggest that it represents a leukemia tumor suppressor.

Suggested Citation

  • Hiroyasu Kidoya & Fumitaka Muramatsu & Teppei Shimamura & Weizhen Jia & Takashi Satoh & Yumiko Hayashi & Hisamichi Naito & Yuya Kunisaki & Fumio Arai & Masahide Seki & Yutaka Suzuki & Tsuyoshi Osawa &, 2019. "Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis," Nature Communications, Nature, vol. 10(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09028-w
    DOI: 10.1038/s41467-019-09028-w
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-019-09028-w
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-019-09028-w?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09028-w. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.