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Auxin Response Factors promote organogenesis by chromatin-mediated repression of the pluripotency gene SHOOTMERISTEMLESS

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Listed:
  • Yuhee Chung

    (University of Pennsylvania)

  • Yang Zhu

    (University of Pennsylvania)

  • Miin-Feng Wu

    (University of Pennsylvania
    Bayer Crop Science)

  • Sara Simonini

    (John Innes Centre, Norwich Research Park
    University of Zurich, Zollikerstrasse 107)

  • Andre Kuhn

    (John Innes Centre, Norwich Research Park)

  • Alma Armenta-Medina

    (Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN))

  • Run Jin

    (University of Pennsylvania)

  • Lars Østergaard

    (John Innes Centre, Norwich Research Park)

  • C. Stewart Gillmor

    (Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN))

  • Doris Wagner

    (University of Pennsylvania)

Abstract

Specification of new organs from transit amplifying cells is critical for higher eukaryote development. In plants, a central stem cell pool maintained by the pluripotency factor SHOOTMERISTEMLESS (STM), is surrounded by transit amplifying cells competent to respond to auxin hormone maxima by giving rise to new organs. Auxin triggers flower initiation through Auxin Response Factor (ARF) MONOPTEROS (MP) and recruitment of chromatin remodelers to activate genes promoting floral fate. The contribution of gene repression to reproductive primordium initiation is poorly understood. Here we show that downregulation of the STM pluripotency gene promotes initiation of flowers and uncover the mechanism for STM silencing. The ARFs ETTIN (ETT) and ARF4 promote organogenesis at the reproductive shoot apex in parallel with MP via histone-deacetylation mediated transcriptional silencing of STM. ETT and ARF4 directly repress STM, while MP acts indirectly, through its target FILAMENTOUS FLOWER (FIL). Our data suggest that – as in animals- downregulation of the pluripotency program is important for organogenesis in plants.

Suggested Citation

  • Yuhee Chung & Yang Zhu & Miin-Feng Wu & Sara Simonini & Andre Kuhn & Alma Armenta-Medina & Run Jin & Lars Østergaard & C. Stewart Gillmor & Doris Wagner, 2019. "Auxin Response Factors promote organogenesis by chromatin-mediated repression of the pluripotency gene SHOOTMERISTEMLESS," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-08861-3
    DOI: 10.1038/s41467-019-08861-3
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