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Outcomes of controlled human malaria infection after BCG vaccination

Author

Listed:
  • Jona Walk

    (Radboud University Medical Center, PO Box 9101
    Radboud University Medical Center PO Box 9101)

  • L. Charlotte J. Bree

    (Radboud University Medical Center PO Box 9101
    Radboud University Medical Center PO Box 9101
    Research Center for Vitamins and Vaccines, Bandim Health Project, Statens Serum Institut
    Odense Patient Data Explorative Network, University of Southern Denmark/Odense University Hospital)

  • Wouter Graumans

    (Radboud University Medical Center, PO Box 9101
    Radboud University Medical Center PO Box 9101)

  • Rianne Stoter

    (Radboud University Medical Center, PO Box 9101
    Radboud University Medical Center PO Box 9101)

  • Geert-Jan Gemert

    (Radboud University Medical Center, PO Box 9101
    Radboud University Medical Center PO Box 9101)

  • Marga Vegte-Bolmer

    (Radboud University Medical Center, PO Box 9101
    Radboud University Medical Center PO Box 9101)

  • Karina Teelen

    (Radboud University Medical Center, PO Box 9101
    Radboud University Medical Center PO Box 9101)

  • Cornelus C. Hermsen

    (Radboud University Medical Center, PO Box 9101
    Radboud University Medical Center PO Box 9101)

  • Rob J. W. Arts

    (Radboud University Medical Center PO Box 9101
    Radboud University Medical Center PO Box 9101)

  • Marije C. Behet

    (Radboud University Medical Center, PO Box 9101
    Radboud University Medical Center PO Box 9101)

  • Farid Keramati

    (Faculty of Science, Radboud university)

  • Simone J. C. F. M. Moorlag

    (Radboud University Medical Center PO Box 9101
    Radboud University Medical Center PO Box 9101)

  • Annie S. P. Yang

    (Radboud University Medical Center, PO Box 9101
    Radboud University Medical Center PO Box 9101)

  • Reinout Crevel

    (Radboud University Medical Center PO Box 9101
    Radboud University Medical Center PO Box 9101)

  • Peter Aaby

    (Research Center for Vitamins and Vaccines, Bandim Health Project, Statens Serum Institut)

  • Quirijn Mast

    (Radboud University Medical Center PO Box 9101
    Radboud University Medical Center PO Box 9101)

  • André J. A. M. Ven

    (Radboud University Medical Center PO Box 9101
    Radboud University Medical Center PO Box 9101)

  • Christine Stabell Benn

    (Research Center for Vitamins and Vaccines, Bandim Health Project, Statens Serum Institut
    Odense Patient Data Explorative Network, University of Southern Denmark/Odense University Hospital)

  • Mihai G. Netea

    (Radboud University Medical Center PO Box 9101
    Radboud University Medical Center PO Box 9101
    Life and Medical Sciences Institute (LIMES), University of Bonn)

  • Robert W. Sauerwein

    (Radboud University Medical Center, PO Box 9101
    Radboud University Medical Center PO Box 9101)

Abstract

Recent evidence suggests that certain vaccines, including Bacillus-Calmette Guérin (BCG), can induce changes in the innate immune system with non-specific memory characteristics, termed ‘trained immunity’. Here we present the results of a randomised, controlled phase 1 clinical trial in 20 healthy male and female volunteers to evaluate the induction of immunity and protective efficacy of the anti-tuberculosis BCG vaccine against a controlled human malaria infection. After malaria challenge infection, BCG vaccinated volunteers present with earlier and more severe clinical adverse events, and have significantly earlier expression of NK cell activation markers and a trend towards earlier phenotypic monocyte activation. Furthermore, parasitemia in BCG vaccinated volunteers is inversely correlated with increased phenotypic NK cell and monocyte activation. The combined data demonstrate that BCG vaccination alters the clinical and immunological response to malaria, and form an impetus to further explore its potential in strategies for clinical malaria vaccine development.

Suggested Citation

  • Jona Walk & L. Charlotte J. Bree & Wouter Graumans & Rianne Stoter & Geert-Jan Gemert & Marga Vegte-Bolmer & Karina Teelen & Cornelus C. Hermsen & Rob J. W. Arts & Marije C. Behet & Farid Keramati & S, 2019. "Outcomes of controlled human malaria infection after BCG vaccination," Nature Communications, Nature, vol. 10(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-08659-3
    DOI: 10.1038/s41467-019-08659-3
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    Cited by:

    1. Krista E. Meijgaarden & Wenchao Li & Simone J. C. F. M. Moorlag & Valerie A. C. M. Koeken & Hans J. P. M. Koenen & Leo A. B. Joosten & Annapurna Vyakarnam & Asma Ahmed & Srabanti Rakshit & Vasista Adi, 2024. "BCG vaccination-induced acquired control of mycobacterial growth differs from growth control preexisting to BCG vaccination," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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