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Tissue-resident Eomes+ NK cells are the major innate lymphoid cell population in human infant intestine

Author

Listed:
  • Adrian F. Sagebiel

    (Leibniz Institute for Experimental Virology)

  • Fenja Steinert

    (Leibniz Institute for Experimental Virology)

  • Sebastian Lunemann

    (Leibniz Institute for Experimental Virology)

  • Christian Körner

    (Leibniz Institute for Experimental Virology)

  • Renée R. C. E. Schreurs

    (University of Amsterdam
    University of Amsterdam)

  • Marcus Altfeld

    (Leibniz Institute for Experimental Virology)

  • Daniel Perez

    (University Medical Center Hamburg-Eppendorf)

  • Konrad Reinshagen

    (University Medical Center Hamburg-Eppendorf)

  • Madeleine J. Bunders

    (Leibniz Institute for Experimental Virology
    University of Amsterdam
    University of Amsterdam)

Abstract

Innate lymphoid cells (ILC), including natural killer (NK) cells, are implicated in host-defense and tissue-growth. However, the composition and kinetics of NK cells in the intestine during the first year of life, when infants are first broadly exposed to exogenous antigens, are still unclear. Here we show that CD103+ NK cells are the major ILC population in the small intestines of infants. When compared to adult intestinal NK cells, infant intestinal NK cells exhibit a robust effector phenotype, characterized by Eomes, perforin and granzyme B expression, and superior degranulation capacity. Absolute intestinal NK cell numbers decrease gradually during the first year of life, coinciding with an influx of intestinal Eomes+ T cells; by contrast, epithelial NKp44+CD69+ NK cells with less cytotoxic capacity persist in adults. In conclusion, NK cells are abundant in infant intestines, where they can provide effector functions while Eomes+ T cell responses mature.

Suggested Citation

  • Adrian F. Sagebiel & Fenja Steinert & Sebastian Lunemann & Christian Körner & Renée R. C. E. Schreurs & Marcus Altfeld & Daniel Perez & Konrad Reinshagen & Madeleine J. Bunders, 2019. "Tissue-resident Eomes+ NK cells are the major innate lymphoid cell population in human infant intestine," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-018-08267-7
    DOI: 10.1038/s41467-018-08267-7
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    Cited by:

    1. L. Krabbendam & B. A. Heesters & C. M. A. Kradolfer & N. J. E. Haverkate & M. A. J. Becker & C. J. Buskens & W. A. Bemelman & J. H. Bernink & H. Spits, 2021. "CD127+ CD94+ innate lymphoid cells expressing granulysin and perforin are expanded in patients with Crohn’s disease," Nature Communications, Nature, vol. 12(1), pages 1-11, December.

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