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Changing temporal context in human temporal lobe promotes memory of distinct episodes

Author

Listed:
  • Mostafa M. El-Kalliny

    (National Institutes of Health)

  • John H. Wittig

    (National Institutes of Health)

  • Timothy C. Sheehan

    (University of California, San Diego)

  • Vishnu Sreekumar

    (National Institutes of Health)

  • Sara K. Inati

    (National Institutes of Health)

  • Kareem A. Zaghloul

    (National Institutes of Health)

Abstract

Memories of experiences that occur around the same time are linked together by a shared temporal context, represented by shared patterns of neural activity. However, shared temporal context may be problematic for selective retrieval of specific memories. Here, we examine intracranial EEG (iEEG) in the human temporal lobe as participants perform a verbal paired associates memory task that requires the encoding of distinct word pairs in memory. We find that the rate of change in patterns of low frequency (3–12 Hz) power distributed across the temporal lobe is significantly related to memory performance. We also find that exogenous electrical stimulation affects how quickly these neural representations of temporal context change with time, which directly affects the ability to successfully form memories for distinct items. Our results indicate that the ability to retrieve distinct episodic memories is related to how quickly neural representations of temporal context change over time during encoding.

Suggested Citation

  • Mostafa M. El-Kalliny & John H. Wittig & Timothy C. Sheehan & Vishnu Sreekumar & Sara K. Inati & Kareem A. Zaghloul, 2019. "Changing temporal context in human temporal lobe promotes memory of distinct episodes," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-018-08189-4
    DOI: 10.1038/s41467-018-08189-4
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    Cited by:

    1. Marcel Bausch & Johannes Niediek & Thomas P. Reber & Sina Mackay & Jan Boström & Christian E. Elger & Florian Mormann, 2021. "Concept neurons in the human medial temporal lobe flexibly represent abstract relations between concepts," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    2. Li Zheng & Zhiyao Gao & Andrew S. McAvan & Eve A. Isham & Arne D. Ekstrom, 2021. "Partially overlapping spatial environments trigger reinstatement in hippocampus and schema representations in prefrontal cortex," Nature Communications, Nature, vol. 12(1), pages 1-15, December.

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