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Central body fatness is a stronger predictor of cancer risk than overall body size

Author

Listed:
  • Amanda M. Barberio

    (Alberta Health Services)

  • Asalah Alareeki

    (University of Calgary)

  • Benjamin Viner

    (Alberta Health Services)

  • Joy Pader

    (Alberta Health Services)

  • Jennifer E. Vena

    (Alberta Health Services)

  • Paul Arora

    (University of Toronto)

  • Christine M. Friedenreich

    (Alberta Health Services
    University of Calgary)

  • Darren R. Brenner

    (Alberta Health Services
    University of Calgary)

Abstract

The importance of body size versus weight distribution for cancer risk is unclear. We investigated associations between measures of body size and shape and the risk of developing cancer. The study population consisted of 26,607 participants from the Alberta’s Tomorrow Project cohort. Two main measures of body shape and size were examined: i) body mass index (BMI) and ii) waist circumference (WC). Incident cancers were identified via linkage to the Alberta Cancer Registry. Cox proportional hazards models were used. Males and females classified as obese (BMI ≥ 30 kg /m−2) have a 33% and 22% increased risk of all-cancer, respectively, than their normal weight counterparts. Similar all-cancer risk increases are observed for those above sex-specific WC guidelines. Mutual adjustment for WC attenuates the association between BMI and all-cancer risk, especially among females. Central adiposity appears to be a stronger predictor of all-cancer risk than body size.

Suggested Citation

  • Amanda M. Barberio & Asalah Alareeki & Benjamin Viner & Joy Pader & Jennifer E. Vena & Paul Arora & Christine M. Friedenreich & Darren R. Brenner, 2019. "Central body fatness is a stronger predictor of cancer risk than overall body size," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-018-08159-w
    DOI: 10.1038/s41467-018-08159-w
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    Cited by:

    1. Francesc Xavier Medina & Josep M. Solé-Sedeno & Anna Bach-Faig & Alicia Aguilar-Martínez, 2021. "Obesity, Mediterranean Diet, and Public Health: A Vision of Obesity in the Mediterranean Context from a Sociocultural Perspective," IJERPH, MDPI, vol. 18(7), pages 1-9, April.
    2. Dorothea Kesztyüs & Josefine Lampl & Tibor Kesztyüs, 2021. "The Weight Problem: Overview of the Most Common Concepts for Body Mass and Fat Distribution and Critical Consideration of Their Usefulness for Risk Assessment and Practice," IJERPH, MDPI, vol. 18(21), pages 1-14, October.

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