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RETRACTED ARTICLE: Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression

Author

Listed:
  • Gui-fang Zhu

    (Southern Medical University
    Southern Medical University
    Key Laboratory of Molecular Tumor Pathology of Guangdong Province)

  • Yang-wei Xu

    (Southern Medical University
    Southern Medical University
    Key Laboratory of Molecular Tumor Pathology of Guangdong Province)

  • Jian Li

    (Southern Medical University
    Southern Medical University
    Key Laboratory of Molecular Tumor Pathology of Guangdong Province)

  • Hui-lin Niu

    (Southern Medical University
    Southern Medical University
    Key Laboratory of Molecular Tumor Pathology of Guangdong Province)

  • Wen-xia Ma

    (Southern Medical University
    Southern Medical University
    Key Laboratory of Molecular Tumor Pathology of Guangdong Province)

  • Jia Xu

    (Icahn School of Medicine at Mount Sinai)

  • Pei-rong Zhou

    (Southern Medical University
    Southern Medical University)

  • Xia Liu

    (Southern Medical University
    Southern Medical University
    Key Laboratory of Molecular Tumor Pathology of Guangdong Province)

  • Dan-li Ye

    (Southern Medical University
    Southern Medical University
    Key Laboratory of Molecular Tumor Pathology of Guangdong Province)

  • Xiao-rong Liu

    (Southern Medical University
    Southern Medical University
    Key Laboratory of Molecular Tumor Pathology of Guangdong Province)

  • Tao Yan

    (Southern Medical University
    Southern Medical University)

  • Wei-ke Zhai

    (Southern Medical University
    Southern Medical University
    Key Laboratory of Molecular Tumor Pathology of Guangdong Province)

  • Zhi-jun Xu

    (Southern Medical University
    Southern Medical University)

  • Chun Liu

    (Southern Medical University
    Southern Medical University)

  • Lei Wang

    (Southern Medical University
    Southern Medical University)

  • Hao Wang

    (Southern Medical University
    Southern Medical University)

  • Jia-mao Luo

    (Southern Medical University
    Southern Medical University)

  • Li Liu

    (Southern Medical University)

  • Xuan-qi Li

    (Southern Medical University)

  • Suiqun Guo

    (Southern Medical University)

  • Hui-ping Jiang

    (Southern Medical University)

  • Peng Shen

    (Southern Medical University)

  • Hui-kuan Lin

    (Wake Forest Baptist Medical Center)

  • Di-hua Yu

    (The University of Texas, MD Anderson Cancer Center)

  • Yan-qing Ding

    (Southern Medical University
    Southern Medical University
    Key Laboratory of Molecular Tumor Pathology of Guangdong Province)

  • Qing-ling Zhang

    (Southern Medical University
    Southern Medical University
    Key Laboratory of Molecular Tumor Pathology of Guangdong Province)

Abstract

Wilms tumor gene on the X chromosome (WTX) is a putative tumor suppressor gene in Wilms tumor, but its expression and functions in other tumors are unclear. Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in women and the second leading cause in men in the United States. We demonstrated that WTX frequently lost in CRC which was highly correlated with cell proliferation, tumor invasion and metastasis. Mechanistically, WTX loss disrupts the interaction between RhoGDIα and CDC42 by losing of the binding with RhoGDIα and triggers the activation of CDC42 and its downstream cascades, which promotes CRC development and liver metastasis. The aberrant upregulation of miR-20a/miR-106a were identified as the reason of WTX loss in CRC both in vivo and in vitro. These study defined the mechanism how miR-20a/miR-106a-mediated WTX loss regulates CRC progression and metastasis, and provided a potential therapeutic target for preventing CRC progression.

Suggested Citation

  • Gui-fang Zhu & Yang-wei Xu & Jian Li & Hui-lin Niu & Wen-xia Ma & Jia Xu & Pei-rong Zhou & Xia Liu & Dan-li Ye & Xiao-rong Liu & Tao Yan & Wei-ke Zhai & Zhi-jun Xu & Chun Liu & Lei Wang & Hao Wang & J, 2019. "RETRACTED ARTICLE: Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-018-07998-x
    DOI: 10.1038/s41467-018-07998-x
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