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Ultrasonic sculpting of virtual optical waveguides in tissue

Author

Listed:
  • Maysamreza Chamanzar

    (Carnegie Mellon University
    University of California)

  • Matteo Giuseppe Scopelliti

    (Carnegie Mellon University)

  • Julien Bloch

    (University of California)

  • Ninh Do

    (University of California)

  • Minyoung Huh

    (University of California)

  • Dongjin Seo

    (University of California)

  • Jillian Iafrati

    (University of California
    University of California)

  • Vikaas S. Sohal

    (University of California
    University of California)

  • Mohammad-Reza Alam

    (University of California)

  • Michel M. Maharbiz

    (University of California
    University of California
    University of California
    Chan Zuckerberg Biohub)

Abstract

Optical imaging and stimulation are widely used to study biological events. However, scattering processes limit the depth to which externally focused light can penetrate tissue. Optical fibers and waveguides are commonly inserted into tissue when delivering light deeper than a few millimeters. This approach, however, introduces complications arising from tissue damage. In addition, it makes it difficult to steer light. Here, we demonstrate that ultrasound can be used to define and steer the trajectory of light within scattering media by exploiting local pressure differences created by acoustic waves that result in refractive index contrasts. We show that virtual light pipes can be created deep into the tissue (>18 scattering mean free paths). We demonstrate the application of this technology in confining light through mouse brain tissue. This technology is likely extendable to form arbitrary light patterns within tissue, extending both the reach and the flexibility of light-based methods.

Suggested Citation

  • Maysamreza Chamanzar & Matteo Giuseppe Scopelliti & Julien Bloch & Ninh Do & Minyoung Huh & Dongjin Seo & Jillian Iafrati & Vikaas S. Sohal & Mohammad-Reza Alam & Michel M. Maharbiz, 2019. "Ultrasonic sculpting of virtual optical waveguides in tissue," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-018-07856-w
    DOI: 10.1038/s41467-018-07856-w
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    Cited by:

    1. Eitan Edrei & Giuliano Scarcelli, 2022. "The overwhelming role of ballistic photons in ultrasonically guided light through tissue," Nature Communications, Nature, vol. 13(1), pages 1-2, December.
    2. Adithya Pediredla & Matteo Giuseppe Scopelliti & Srinivasa Narasimhan & Maysamreza Chamanzar & Ioannis Gkioulekas, 2023. "Optimized virtual optical waveguides enhance light throughput in scattering media," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    3. Maysamreza Chamanzar & Matteo Giuseppe Scopelliti & Adithya Pediredla & Hengji Huang & Srinivasa G. Narasimhan & Ioannis Gkioulekas & Mohammad-Reza Alam & Michel M. Maharbiz, 2022. "Reply to: The overwhelming role of ballistic photons in ultrasonically guided light through tissue," Nature Communications, Nature, vol. 13(1), pages 1-5, December.

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