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Water Mediated One Pot Synthesis of pyrazolo[1,5-a] Pyrimidine Derivatives and their Antimicrobial Activity

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  • Jayesh Babariya
  • Yogesh T. Naliapara

Abstract

In this paper we have described the water mediated synthesis of substituted triazolopyrimidine derivatives in moderate to good yield. The reaction of various substituted aldehydes with 1-(3,4-dimethoxyphenyl)-4,4,4-trifluorobutane-1,3-dione as active methylene compound and 5-amino-3-(methylthio)-1H-pyrazole-4-carbonitrile afforded the triazolo pyrimidine derivatives in the presence boric acid and water as a solvent. We have also optimized the reaction condition using the various solvent. We have confirmed the structure on the basis of spectroscopic technique. All the synthesized compounds were evaluated for their antimicrobial activity. The investigation of antimicrobial and antifungal screening data revealed that all the tested compounds showed moderate to significant activity.

Suggested Citation

  • Jayesh Babariya & Yogesh T. Naliapara, 2017. "Water Mediated One Pot Synthesis of pyrazolo[1,5-a] Pyrimidine Derivatives and their Antimicrobial Activity," International Journal of Scientific Research in Science, Engineering and Technology, International Journal of Scientific Research in Science, Engineering and Technology, vol. 3(6), pages 654-663, October.
    • Handle: RePEc:ijs:ijsrse:v3:y2017:i6:id:hijsrset1736136
    Note: Article URL: https://ijsrset.com/IJSRSET1736136
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