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Assessment of Transforming Growth Factor β1 and DNA Cell Cycle in Egyptian Patients with Chronic Hepatitis-C Virus and Hepatocellular Carcinoma

Author

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  • Zahran Faten
  • El- Emshaty Hoda
  • Gouida Mona
  • Hussien Mohamed

Abstract

Hepatocellular carcinoma (HCC) is the end-stage of chronic liver diseases (CLDs). The main aetiologies of CLDs are chronic hepatitis C virus (HCV) infection. The aim of this work was to evaluate diagnostic value of TGF-β1 in patients with chronic liver disease (CLD) Fibrosis, HCC and healthy individuals. The present study included 51 patients with Fibrosis (F2-F4), 30 Hepatocellular Carcinoma (HCC) patients, in addition 40 normal healthy individuals were enrolled in this study as control group. AFP and CEA were estimated in all groups. TGF-β1 and DNA Cell Cycle were estimated using Flow Cytometry technique. Results from this study revealed that there was high significance difference in APRI ratio, FIB-4 ratio between HCC, Fibrosis comparing with Control group (p

Suggested Citation

  • Zahran Faten & El- Emshaty Hoda & Gouida Mona & Hussien Mohamed, 2017. "Assessment of Transforming Growth Factor β1 and DNA Cell Cycle in Egyptian Patients with Chronic Hepatitis-C Virus and Hepatocellular Carcinoma," International Journal of Scientific Research in Science, Engineering and Technology, International Journal of Scientific Research in Science, Engineering and Technology, vol. 3(2), pages 769-774, April.
    • Handle: RePEc:ijs:ijsrse:v3:y2017:i2:id:hijsrset1732149
    Note: Article URL: https://ijsrset.com/IJSRSET1732149
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