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Mathematical Modeling of the Dynamics of Female Genital Schistosomiasis as a Risk Factor to Cervical Cancer

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  • Brenda Achieng Onyango
  • Michael Onyango Ojiema

Abstract

Female genital schistosomiasis (FGS), caused by chronic infection with Schistosoma haematobium, represents a significant but neglected gynecological condition that affects approximately 56 million women in sub-Saharan Africa. This parasitic disease manifests itself through chronic inflammation and tissue damage in the female genital tract, leading to substantial morbidity and poor quality of life. Emerging epidemiological evidence suggests that FGS may function as an important cofactor in cervical carcinogenesis, potentially explaining the elevated burden of cervical cancer observed in schistosomiasis-endemic regions. However, the population level impact of this relationship and optimal intervention strategies remains poorly quantified. This study develops a compartmental mathematical model that integrates the transmission dynamics of schistosomiasis with human papilloma virus (HPV)–induced cervical carcinogenesis pathways. The model explicitly incorporates key biological mechanisms including chronic inflammation, immunomodulation, and synergistic interactions between FGS and HPV infection. The analytical derivation of the basic reproduction number yields R0=maxβSγ+τS+μ+βHPVγγ+τS+με+μ,βHPVε+μ, with the bifurcation analysis confirming a forward transcritical bifurcation at R0=1 (coefficients a 0). This establishes R0

Suggested Citation

  • Brenda Achieng Onyango & Michael Onyango Ojiema, 2026. "Mathematical Modeling of the Dynamics of Female Genital Schistosomiasis as a Risk Factor to Cervical Cancer," Abstract and Applied Analysis, Hindawi, vol. 2026, pages 1-20, June.
    • Handle: RePEc:hin:jnlaaa:3242606
    DOI: 10.1155/aaa/3242606
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