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On the Appropriateness of Fixed Correlation Assumptions in Repeated-Measures Meta-Analysis: A Monte Carlo Assessment

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  • Vasileios Papadopoulos

    (Laboratory of Anatomy, Department of Medicine, Democritus University of Thrace, GR-68100 Alexandroupolis, Greece)

Abstract

In repeated-measures meta-analyses, raw data are often unavailable, preventing the calculation of the correlation coefficient r between pre- and post-intervention values. As a workaround, many researchers adopt a heuristic approximation of r = 0.7. However, this value lacks rigorous mathematical justification and may introduce bias into variance estimates of pre/post-differences. We employed Monte Carlo simulations (n = 500,000 per scenario) in Fisher z-space to examine the distribution of the standard deviation of pre-/post-differences ( σ D ) under varying assumptions of r and its uncertainty ( σ r ). Scenarios included r = 0.5, 0.6, 0.707, 0.75, and 0.8, each tested across three levels of variance ( σ r = 0.05, 0.1, and 0.15). The approximation of r = 0.75 resulted in a balanced estimate of σ D , corresponding to a “midway” variance attenuation due to paired data. This value more accurately offsets the deficit caused by assuming a correlation, compared to the traditional value of 0.7. While the r = 0.7 heuristic remains widely used, our results support the use of r = 0.75 as a more mathematically neutral and empirically defensible alternative in repeated-measures meta-analyses lacking raw data.

Suggested Citation

  • Vasileios Papadopoulos, 2025. "On the Appropriateness of Fixed Correlation Assumptions in Repeated-Measures Meta-Analysis: A Monte Carlo Assessment," Stats, MDPI, vol. 8(3), pages 1-9, August.
  • Handle: RePEc:gam:jstats:v:8:y:2025:i:3:p:72-:d:1723582
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