IDEAS home Printed from https://ideas.repec.org/a/gam/jmathe/v11y2023i7p1640-d1109838.html
   My bibliography  Save this article

Kidney Transplant: Survival Analysis and Prognostic Factors after 10 Years of Follow-Up

Author

Listed:
  • Álvaro Beviá-Romero

    (Urology Department, La Fe University and Polytechnique Hospital, 46026 Valencia, Spain)

  • Francisco Quereda-Flores

    (Urology Department, La Fe University and Polytechnique Hospital, 46026 Valencia, Spain)

  • Javier Díaz-Carnicero

    (Research Centre for Health Economics and Management, Universitat Politècnica de València, 46022 Valencia, Spain)

  • Francisco Gómez-Palomo

    (Urology Department, La Fe University and Polytechnique Hospital, 46026 Valencia, Spain)

  • María Ramos-Cebrián

    (Nephrology Department, La Fe University and Polytechnique Hospital, 46026 Valencia, Spain)

  • Joaquín Espinosa-Vañó

    (Urology Department, La Fe University and Polytechnique Hospital, 46026 Valencia, Spain)

  • Dario J. Castillo-Antón

    (Urology Department, La Fe University and Polytechnique Hospital, 46026 Valencia, Spain)

  • Enrique Broseta-Rico

    (Urology Department, La Fe University and Polytechnique Hospital, 46026 Valencia, Spain)

  • David Vivas-Consuelo

    (Research Centre for Health Economics and Management, Universitat Politècnica de València, 46022 Valencia, Spain)

  • Alberto Budía-Alba

    (Urology Department, La Fe University and Polytechnique Hospital, 46026 Valencia, Spain)

Abstract

The aim of this work is to analyse recipient and graft survival after kidney transplant in a three-year cohort and to identify predictive factors with up to 10 years of follow-up. Methods: retrospective consecutive cohort study of 250 kidney transplant recipients operated between 2010 and 2012. Multiorganic transplants and both dead-donor and living-donor transplants were included. Data were collected from electronic health records. A survival analysis was conducted using the Kaplan-Meier method and a Cox proportional-hazards multivariate model. Results: mean follow-up was 8.1 ± 3.2 years. Graft survival at 2, 5 and 10 years was 89.0%, 85.1% and 78.4% respectively. The multivariate model identified the following risk factors for graft loss: diabetic nephropathy (HR 3.2 CI95% [1.1–9.4]), delayed graft function (3.8 [2.0–7.4]), chronic kidney rejection (3.7 [1.2–11.4]), and early surgical complications (2.6 [1.4–5.1]). Conversely, combined transplant was found to be a protective factor for graft loss (0.1 [0.0–0.5]). Recipient patient survival was 94.3%, 90.0% and 76.6% at 2, 5 and 10 years respectively. The model identified the following mortality risk factors: older recipient age (1.1 [1.1–1.2]), combined transplant (7.6 [1.7–34.5]) and opportunistic infections (2.6 [1.3–5.0]). Conclusions: 10-year recipient and graft survival were 76.6% and 78.4% respectively. Main mortality risk factors were older recipient age, opportunistic infections and multiorganic transplant. Main graft loss risk factors were diabetic nephropathy, delayed graft function, chronic kidney rejection and early surgical complications.

Suggested Citation

  • Álvaro Beviá-Romero & Francisco Quereda-Flores & Javier Díaz-Carnicero & Francisco Gómez-Palomo & María Ramos-Cebrián & Joaquín Espinosa-Vañó & Dario J. Castillo-Antón & Enrique Broseta-Rico & David V, 2023. "Kidney Transplant: Survival Analysis and Prognostic Factors after 10 Years of Follow-Up," Mathematics, MDPI, vol. 11(7), pages 1-12, March.
  • Handle: RePEc:gam:jmathe:v:11:y:2023:i:7:p:1640-:d:1109838
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/2227-7390/11/7/1640/pdf
    Download Restriction: no

    File URL: https://www.mdpi.com/2227-7390/11/7/1640/
    Download Restriction: no
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jmathe:v:11:y:2023:i:7:p:1640-:d:1109838. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.