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Toxicity of the Herbicide Atrazine: Effects on Lipid Peroxidation and Activities of Antioxidant Enzymes in the Freshwater Fish Channa P unctatus (Bloch)

Author

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  • Christopher Ddidigwu Nwani

    (Department of Applied Biology, Ebonyi State University, PMB 053, Abakaliki, Ebonyi State, Nigeria
    National Bureau of Fish Genetic Resources (Indian Council of Agricultural Research), Canal Ring Road, PO- Dilkusha Lucknow 226 002 (UP), India)

  • Wazir Singh Lakra

    (National Bureau of Fish Genetic Resources (Indian Council of Agricultural Research), Canal Ring Road, PO- Dilkusha Lucknow 226 002 (UP), India)

  • Naresh Sahebrao Nagpure

    (National Bureau of Fish Genetic Resources (Indian Council of Agricultural Research), Canal Ring Road, PO- Dilkusha Lucknow 226 002 (UP), India)

  • Ravindra Kumar

    (National Bureau of Fish Genetic Resources (Indian Council of Agricultural Research), Canal Ring Road, PO- Dilkusha Lucknow 226 002 (UP), India)

  • Basdeo Kushwaha

    (National Bureau of Fish Genetic Resources (Indian Council of Agricultural Research), Canal Ring Road, PO- Dilkusha Lucknow 226 002 (UP), India)

  • Satish Kumar Srivastava

    (National Bureau of Fish Genetic Resources (Indian Council of Agricultural Research), Canal Ring Road, PO- Dilkusha Lucknow 226 002 (UP), India)

Abstract

The present study was undertaken to evaluate the toxicity and effects of a commercial formulation of the herbicide atrazine (Rasayanzine) on lipid peroxidation and antioxidant enzyme system in the freshwater air breathing fish Channa punctatus . The 12, 24, 48, 72 and 96 h LC 50 of atrazine, calculated by probit analysis, were determined to be 77.091, 64.053, 49.100, 44.412 and 42.381 mg·L -1 , respectively, in a semi static system with significant difference (p 10-90 values obtained for different times of exposure. In addition to concentration and time dependent decrease in mortality rate, stress signs in the form of behavioral changes were also observed in response to the test chemical. In fish exposed for 15 days to different sublethal concentrations of the herbicide (1/4 LC 50 = ~10.600 mg·L -1 , 1/8 LC 50 = ~5.300 mg·L -1 and 1/10 LC 50 = ~4.238 mg·L -1 ) induction of oxidative stress in the liver was evidence by increased lipid peroxidation levels. The antioxidants superoxide dismutase (SOD), catalase (CAT) and glutathione reductase (GR) responded positively in a concentration dependent pattern, thus, suggesting the use of these antioxidants as potential biomarkers of toxicity associated with contaminations exposure in freshwater fishes.

Suggested Citation

  • Christopher Ddidigwu Nwani & Wazir Singh Lakra & Naresh Sahebrao Nagpure & Ravindra Kumar & Basdeo Kushwaha & Satish Kumar Srivastava, 2010. "Toxicity of the Herbicide Atrazine: Effects on Lipid Peroxidation and Activities of Antioxidant Enzymes in the Freshwater Fish Channa P unctatus (Bloch)," IJERPH, MDPI, vol. 7(8), pages 1-15, August.
    • Handle: RePEc:gam:jijerp:v:7:y:2010:i:8:p:3298-3312:d:9376
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    References listed on IDEAS

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    1. E. O. Farombi & Y. R. Ajimoko & O. A. Adelowo, 2008. "Effect of Butachlor on Antioxidant Enzyme Status and Lipid Peroxidation in Fresh Water African Catfish, ( Clarias gariepinus )," IJERPH, MDPI, vol. 5(5), pages 1-5, December.
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    Cited by:

    1. Patharanun Toolkiattiwong & Noppol Arunrat & Sukanya Sereenonchai, 2023. "Environmental, Human and Ecotoxicological Impacts of Different Rice Cultivation Systems in Northern Thailand," IJERPH, MDPI, vol. 20(3), pages 1-18, February.
    2. Moses New-Aaron & Olufemi Abimbola & Raheleh Mohammadi & Oluwaseun Famojuro & Zaeema Naveed & Azar Abadi & Jesse E. Bell & Shannon Bartelt-Hunt & Eleanor G. Rogan, 2021. "Low-Level Groundwater Atrazine in High Atrazine Usage Nebraska Counties: Likely Effects of Excessive Groundwater Abstraction," IJERPH, MDPI, vol. 18(24), pages 1-19, December.

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