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Human Health Risk Assessment from the Tilapia Fish in Heavy Metal–Contaminated Landfill Reservoir

Author

Listed:
  • Ni Yang

    (Toxic Substances, Microorganisms and Feed Additives in Livestock and Aquatic Animals for Food Safety Research Program, Khon Kaen University, Khon Kaen 40002, Thailand
    Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen 40002, Thailand)

  • Pansa Monkheang

    (Yasothon Agricultural Research and Development Center, Department of Agriculture, Ministry of Agriculture, Yasothon 35000, Thailand)

  • Lamyai Neeratanaphan

    (Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand)

  • Somsak Intamat

    (Thatphanom Crown Prince Hospital, Nakornphanom 48110, Thailand)

  • Bundit Tengjaroensakul

    (Toxic Substances, Microorganisms and Feed Additives in Livestock and Aquatic Animals for Food Safety Research Program, Khon Kaen University, Khon Kaen 40002, Thailand
    Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen 40002, Thailand)

Abstract

This study highlights the significant environmental and health risks associated with heavy metal contamination (As, Cd, Cr, and Pb) in Oreochromis niloticus (Nile tilapia) from two locations: the Khon Kaen municipal landfill (study site) and the Thapra commercial fish farm (reference site). It also evaluates potential human health risks and investigates genotoxicity and oxidative stress markers, including malondialdehyde, hydrogen peroxide (H 2 O 2 ), catalase (CAT), and superoxide dismutase (SOD) in fish. Heavy metal concentrations were analyzed using inductively coupled plasma optical emission spectrometry. To determine genetic differentiation, inter-simple sequence repeats with dendrogram construction and genomic template stability (%GTS) were applied. The results showed that the average concentrations of As, Cd, Cr, and Pb in water samples were 0.0848, 0.536, 1.23, and 0.73 mg/L, respectively. These values exceeded safety limits, and the average Cd in sediment (1.162 mg/kg) was above regulatory thresholds. In fish muscle, the average metal concentrations (mg/kg) followed the order Cr (1.83) > Pb (0.69) > Cd (0.096) > As (0.0758), with Pb exceeding food quality standards. The bioaccumulation factor ranked as Cr > Pb > As > Cd. Health risk assessments, including health risk index and carcinogenic risk, suggested Pb contamination poses significant health risks through fish consumption. From dendrogram results, the %GTS of O. niloticus from the landfill and reference sites were 46.34 to 71.67% and 87.34 to 96.00%, respectively. This suggests that fish from the landfill site exhibited greater genetic diversity compared to those from the reference site. Specific oxidative stress markers revealed higher levels of H 2 O 2 and significantly lower activities of CAT and SOD in landfill O. niloticus than in the reference site. These results emphasize the urgent need for environmental monitoring, stricter pollution controls, and improved waste management strategies to protect aquatic ecosystems and human health.

Suggested Citation

  • Ni Yang & Pansa Monkheang & Lamyai Neeratanaphan & Somsak Intamat & Bundit Tengjaroensakul, 2025. "Human Health Risk Assessment from the Tilapia Fish in Heavy Metal–Contaminated Landfill Reservoir," IJERPH, MDPI, vol. 22(6), pages 1-18, May.
    • Handle: RePEc:gam:jijerp:v:22:y:2025:i:6:p:873-:d:1669479
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    References listed on IDEAS

    as
    1. Rachaneekorn Mingkhwan & Suwalee Worakhunpiset, 2018. "Heavy Metal Contamination Near Industrial Estate Areas in Phra Nakhon Si Ayutthaya Province, Thailand and Human Health Risk Assessment," IJERPH, MDPI, vol. 15(9), pages 1-10, August.
    2. Hatem Mohamed & Parvez I. Haris & Eid I. Brima, 2017. "Estimated Dietary Intakes of Toxic Elements from Four Staple Foods in Najran City, Saudi Arabia," IJERPH, MDPI, vol. 14(12), pages 1-14, December.
    3. Lamyai Neeratanaphan & Chuchart Kamollerd & Pimchanok Suwannathada & Pongthorn Suwannathada & Bundit Tengjaroenkul, 2020. "Genotoxicity and Oxidative Stress in Experimental Hybrid Catfish Exposed to Heavy Metals in a Municipal Landfill Reservoir," IJERPH, MDPI, vol. 17(6), pages 1-14, March.
    Full references (including those not matched with items on IDEAS)

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