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Health Disparities at the Intersection of Racism, Social Determinants of Health, and Downstream Biological Pathways

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  • Roland J. Thorpe

    (Program for Research on Men’s Health, Hopkins Center for Health Disparities Solutions, Baltimore, MD 21205, USA
    Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA)

  • Marino A. Bruce

    (Faith, Justice and Health Collaboratory, University of Houston Population Health, University of Houston, Houston, TX 77204, USA
    Department of Behavioral and Social Sciences, University of Houston, Tilman J. Fertitta Family College of Medicine, Houston, TX 77204, USA)

  • Tanganyika Wilder

    (School of Allied Health Sciences, Division of Health Sciences, Florida A&M University, Tallahassee, FL 32317, USA)

  • Harlan P. Jones

    (Department of Microbiology, Immunology and Genetics, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Institute for Health Disparities, University of North Texas Health Science Center, Fort Worth, TX 76107, USA)

  • Courtney Thomas Tobin

    (Department of Community Health Sciences, Fielding School of Public Health, University of California, Los Angeles, CA 90995, USA)

  • Keith C. Norris

    (Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine at UCLA, Los Angeles, CA 90024, USA)

Abstract

Despite overall improvements in the accessibility, quality, and outcomes of care in the U.S. health care system over the last 30 years, a large proportion of marginalized racial and ethnic minority (minoritized) groups continue to suffer from worse outcomes across most domains. Many of these health disparities are driven by inequities in access to and the scope of society’s health-affirming structural resources and opportunities commonly referred to as structural drivers or social determinants of health—SDoH. Persistently health-undermining factors in the social environment and the downstream effects of these inequities on neurocognitive and biological pathways exacerbate these disparities. The consequences of these circumstances manifest as behavioral, neurohormonal, immune, and inflammatory and oxidative stress responses, as well as epigenetic changes. We propose a theoretical model of the interdependent characteristics of inequities in the SDoH driven by race-based discriminatory laws, policies, and practices that eventually culminate in poor health outcomes. This model provides a framework for developing and validating multi-level interventions designed to target root causes, thereby lessening health disparities and accelerating improved health outcomes for minoritized groups.

Suggested Citation

  • Roland J. Thorpe & Marino A. Bruce & Tanganyika Wilder & Harlan P. Jones & Courtney Thomas Tobin & Keith C. Norris, 2025. "Health Disparities at the Intersection of Racism, Social Determinants of Health, and Downstream Biological Pathways," IJERPH, MDPI, vol. 22(5), pages 1-11, April.
    • Handle: RePEc:gam:jijerp:v:22:y:2025:i:5:p:703-:d:1645593
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    References listed on IDEAS

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