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HLA Polymorphisms Linked to the Severity and Extent of Periodontitis in Patients with Type 1 Diabetes from a Brazilian Mixed Population

Author

Listed:
  • Carlos Felipe Sousa Menezes

    (School of Dentistry, Federal University of Maranhão, São Luís 65085-580, MA, Brazil)

  • Lucas Meneses Lage

    (School of Dentistry, Federal University of Maranhão, São Luís 65085-580, MA, Brazil)

  • Luís Gustavo Souza Santos

    (School of Dentistry, Federal University of Maranhão, São Luís 65085-580, MA, Brazil)

  • Gilvan Cortês Nascimento

    (Research Group in Clinical Endocrinology and Molecular Metabolism, São Luís 65020-070, MA, Brazil
    School of Medicine, Federal University of Maranhão, São Luís 65020-240, MA, Brazil)

  • Marcelo Magalhães

    (Research Group in Clinical Endocrinology and Molecular Metabolism, São Luís 65020-070, MA, Brazil
    Graduate Program in Adult Health, Federal University of Maranhão, São Luís 65085-580, MA, Brazil)

  • Alexandre Facundo

    (Research Group in Clinical Endocrinology and Molecular Metabolism, São Luís 65020-070, MA, Brazil)

  • Dayse Aparecida Silva

    (DNA Diagnostic Laboratory, Rio de Janeiro State University, Rio de Janeiro 20550-900, RJ, Brazil)

  • Luís Cristóvão Porto

    (DNA Diagnostic Laboratory, Rio de Janeiro State University, Rio de Janeiro 20550-900, RJ, Brazil)

  • Marília Brito Gomes

    (Diabetes Unit, State University of Rio de Janeiro, Rio de Janeiro 20551-030, RJ, Brazil)

  • Manuel dos Santos Faria

    (Research Group in Clinical Endocrinology and Molecular Metabolism, São Luís 65020-070, MA, Brazil
    Graduate Program in Adult Health, Federal University of Maranhão, São Luís 65085-580, MA, Brazil)

  • Rossana Sousa Azulay

    (Research Group in Clinical Endocrinology and Molecular Metabolism, São Luís 65020-070, MA, Brazil
    Graduate Program in Adult Health, Federal University of Maranhão, São Luís 65085-580, MA, Brazil)

  • Vandilson Rodrigues

    (School of Dentistry, Federal University of Maranhão, São Luís 65085-580, MA, Brazil
    Research Group in Clinical Endocrinology and Molecular Metabolism, São Luís 65020-070, MA, Brazil
    Graduate Program in Adult Health, Federal University of Maranhão, São Luís 65085-580, MA, Brazil)

Abstract

This study aimed to investigate the relationship between Class II human leukocyte antigen (HLA) alleles (DRB1, DQA1, and DQB1) and the severity and extent of periodontitis in patients with Type 1 diabetes (T1D). A cross-sectional study was conducted with 49 patients with T1D. Demographic data and diabetes history were collected. A clinical examination was performed to assess periodontal variables. The patients were categorized by the periodontitis severity and the extent of periodontitis. Peripheral blood samples were analyzed to identify the percentage of autosomal ancestry (Native American, European, and African) and the HLA-DRB1*, HLA-DQA1*, and HLA-DQB1* alleles. The DRB1*03 and DRB1*15 haplogroups were significantly associated with an increased risk of generalized periodontitis (OR = 19.8, 95% CI = 1.14–346, p = 0.003; OR = 41.2, 95% CI = 1.85–917, p < 0.001) and severe periodontitis (OR = 7.7, 95% CI = 1.68–35.5, p = 0.003; OR = 21.2, 95% CI = 0.97–461, p = 0.005). No associations were observed between the HLA-DQA1 and HLA-DQB1 alleles and periodontitis. These findings suggest that patients with T1D from a highly mixed Brazilian population carrying the DRB1*03 and DRB1*15 haplogroups are at higher risk for developing more severe and generalized forms of periodontitis.

Suggested Citation

  • Carlos Felipe Sousa Menezes & Lucas Meneses Lage & Luís Gustavo Souza Santos & Gilvan Cortês Nascimento & Marcelo Magalhães & Alexandre Facundo & Dayse Aparecida Silva & Luís Cristóvão Porto & Marília, 2025. "HLA Polymorphisms Linked to the Severity and Extent of Periodontitis in Patients with Type 1 Diabetes from a Brazilian Mixed Population," IJERPH, MDPI, vol. 22(4), pages 1-13, March.
    • Handle: RePEc:gam:jijerp:v:22:y:2025:i:4:p:512-:d:1622213
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