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Adherence to Antihypertensive Therapy: A Cross-Sectional Study Among Patients in the Republic of Kazakhstan

Author

Listed:
  • Akbayan Markabayeva

    (Department of Family Medicine No. 2, NJSC “Astana Medical University”, Beibitshilik Str. 49a, Astana 010000, Kazakhstan)

  • Aiman Kerimkulova

    (Department of Family Medicine No. 2, NJSC “Astana Medical University”, Beibitshilik Str. 49a, Astana 010000, Kazakhstan)

  • Riza Nurpeissova

    (Department of Family Medicine No. 2, NJSC “Astana Medical University”, Beibitshilik Str. 49a, Astana 010000, Kazakhstan)

  • Gyulnar Zhussupova

    (Heart Rhythm Research Institute, NJSC “Astana Medical University”, Beibitshilik Str. 49a, Astana 010000, Kazakhstan)

  • Ayagyoz Umbetzhanova

    (Department of General Practice with the Course of Evidence-Based Medicine, NJSC “Astana Medical University”, Beibitshilik Str. 49a, Astana 010000, Kazakhstan)

  • Dinara Zhunussova

    (Department of General Practice with the Course of Evidence-Based Medicine, NJSC “Astana Medical University”, Beibitshilik Str. 49a, Astana 010000, Kazakhstan)

  • Alisher Idrisov

    (Department of Family Medicine No. 2, NJSC “Astana Medical University”, Beibitshilik Str. 49a, Astana 010000, Kazakhstan)

  • Ardak Zhumagaliyeva

    (Department of Family Medicine No. 2, NJSC “Astana Medical University”, Beibitshilik Str. 49a, Astana 010000, Kazakhstan)

  • Aliya Seidullayeva

    (Department of Pediatric Infectious Diseases, NJSC “Astana Medical University”, Beibitshilik Str. 49a, Astana 010000, Kazakhstan)

  • Aigul Utegenova

    (Department of Microbiology and Virology, NJSC “Astana Medical University”, Beibitshilik Str. 49a, Astana 010000, Kazakhstan)

  • Lyudmila Pivina

    (Department of Emergency Medicine, NJSC “Semey Medical University”, Abay Str. 103, Semey 071400, Kazakhstan)

Abstract

Background: Poor adherence to antihypertensive therapy is a major barrier to effective blood pressure control, particularly in countries with a high burden of non-communicable diseases. In Kazakhstan, improving adherence is a key objective of the “Densaulyk” State Health Program (2020–2025). Objective: To assess medication adherence among patients with arterial hypertension in Kazakhstan and identify associated socio-demographic and clinical factors. Methods: A cross-sectional survey was conducted among outpatient hypertensive patients at a major urban medical center. Adherence was measured using the 8-item Morisky Medication Adherence Scale (MMAS-8). Socio-demographic characteristics, disease duration, and the number of prescribed medications were analyzed in relation to adherence levels. Results: Adherence was significantly associated with age, ethnicity, education, marital and financial status, disease duration, and treatment complexity. A notable share of participants demonstrated low to moderate adherence. The use of self-reported data may have introduced bias. Conclusions: Medication adherence in Kazakhstan is influenced by multiple interrelated factors. Targeted and culturally appropriate interventions—such as simplified regimens, digital tools, and broader access to subsidized drugs—are essential to improve long-term outcomes in hypertension management.

Suggested Citation

  • Akbayan Markabayeva & Aiman Kerimkulova & Riza Nurpeissova & Gyulnar Zhussupova & Ayagyoz Umbetzhanova & Dinara Zhunussova & Alisher Idrisov & Ardak Zhumagaliyeva & Aliya Seidullayeva & Aigul Utegenov, 2025. "Adherence to Antihypertensive Therapy: A Cross-Sectional Study Among Patients in the Republic of Kazakhstan," IJERPH, MDPI, vol. 22(10), pages 1-14, September.
    • Handle: RePEc:gam:jijerp:v:22:y:2025:i:10:p:1483-:d:1758285
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    References listed on IDEAS

    as
    1. Rasha Khatib & Jon-David Schwalm & Salim Yusuf & R Brian Haynes & Martin McKee & Maheer Khan & Robby Nieuwlaat, 2014. "Patient and Healthcare Provider Barriers to Hypertension Awareness, Treatment and Follow Up: A Systematic Review and Meta-Analysis of Qualitative and Quantitative Studies," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-12, January.
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