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Polypharmacy Management in a Gender Perspective: At the Heart of the Problem: Analysis of Major Cardiac Diseases, SARS-CoV-2 Affection and Gender Distribution in a Cohort of Patients in Internal Medicine Ward

Author

Listed:
  • Filomena Pietrantonio

    (Ospedale dei Castelli, Local Health Authority Roma 6, 00041 Albano Laziale, Italy
    National Centre for Health Technology Assessment, National Health Institute, 00153 Rome, Italy)

  • Angela Ciamei

    (Ospedale dei Castelli, Local Health Authority Roma 6, 00041 Albano Laziale, Italy
    Angela Ciamei and Antonio Vinci collaborated in the same way in the drafting of the article.)

  • Antonio Vinci

    (Department of Biomedicine and Prevention, University of Rome “Tor Vergata”, 00133 Rome, Italy
    Angela Ciamei and Antonio Vinci collaborated in the same way in the drafting of the article.)

  • Tiziana Ciarambino

    (Department of Internal Medicine, Luigi Vanvitelli University, 81100 Caserta, Italy)

  • Elena Alessi

    (Ospedale dei Castelli, Local Health Authority Roma 6, 00041 Albano Laziale, Italy)

  • Matteo Pascucci

    (Ospedale dei Castelli, Local Health Authority Roma 6, 00041 Albano Laziale, Italy)

  • Michela Delli Castelli

    (Ospedale dei Castelli, Local Health Authority Roma 6, 00041 Albano Laziale, Italy)

  • Silvia Zito

    (Ospedale dei Castelli, Local Health Authority Roma 6, 00041 Albano Laziale, Italy)

  • Simona Sanguedolce

    (Ospedale dei Castelli, Local Health Authority Roma 6, 00041 Albano Laziale, Italy)

  • Marianna Rainone

    (Ospedale dei Castelli, Local Health Authority Roma 6, 00041 Albano Laziale, Italy)

  • Jacopo Di Lorenzo

    (Ospedale dei Castelli, Local Health Authority Roma 6, 00041 Albano Laziale, Italy)

  • Fabio Vinci

    (Ospedale dei Castelli, Local Health Authority Roma 6, 00041 Albano Laziale, Italy)

  • Giulia Laurelli

    (Ospedale dei Castelli, Local Health Authority Roma 6, 00041 Albano Laziale, Italy)

  • Claudia Di Iorio

    (Ospedale dei Castelli, Local Health Authority Roma 6, 00041 Albano Laziale, Italy)

  • Roberto Corsi

    (Health Management, Local Health Authority Roma 6, 00041 Albano Laziale, Italy)

  • Serafino Ricci

    (Department of Hystological, Anatomical Sciences and Legal Medicine, Sapienza-University of Rome, 00196 Rome, Italy)

  • Alessandra Di Berardino

    (Ospedale dei Castelli, Local Health Authority Roma 6, 00041 Albano Laziale, Italy)

  • Matteo Ruggeri

    (National Centre for Health Technology Assessment, National Health Institute, 00153 Rome, Italy
    HTA Center, St. Camillus University of Medicine and Health Sciences, 00131 Rome, Italy)

  • Francesco Rosiello

    (Ospedale dei Castelli, Local Health Authority Roma 6, 00041 Albano Laziale, Italy
    Department of Hystological, Anatomical Sciences and Legal Medicine, Sapienza-University of Rome, 00196 Rome, Italy)

Abstract

Background: COVID-19 patients with any pre-existing major cardio-vascular disease (CVD) are at the highest risk of viral infection and of developing severe disease. The pathophysiological mechanism is characterized by the viral link to angiotensin-converting enzyme 2 (ACE2) and the involvement of the endothelial system with the release of cytokines and the inflicting of direct damage to the myocardium, the induction of microthrombosis, and the initiation of alterations in oxygen diffusion. The aim of the study is to analyze the clinical course and outcomes in patients (gender-stratified) with pre-existing major CVD. Methods: Out of the 1833 (973 M/860 F) patients admitted to the Internal Medicine COVID-19 Unit of “Castelli Hospital”, Lazio, Italy, from 1 January 2021 to 31 December 2021, 600 patients (320 M/280 F) with a mean age of 77 (78.6 M/75.1 F) previously had CVD. Demographic characteristics, length of the stay (LOS) and oxygen therapy were evaluated. Results: All of the CVD COVID-19 patients underwent non-invasive ventilation (NIV). CVD was linked with increased LOS (21 days F/22 M) compared to no CVD (19 days). In total, 32.7% of total patients had major CVD. Conclusions: Timely identification and evaluation of patients with pre-existing major CVD are fundamental for adequate treatment based on gender, severity, state of illness and for risk reduction.

Suggested Citation

  • Filomena Pietrantonio & Angela Ciamei & Antonio Vinci & Tiziana Ciarambino & Elena Alessi & Matteo Pascucci & Michela Delli Castelli & Silvia Zito & Simona Sanguedolce & Marianna Rainone & Jacopo Di L, 2023. "Polypharmacy Management in a Gender Perspective: At the Heart of the Problem: Analysis of Major Cardiac Diseases, SARS-CoV-2 Affection and Gender Distribution in a Cohort of Patients in Internal Medic," IJERPH, MDPI, vol. 20(9), pages 1-11, May.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:9:p:5711-:d:1138752
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    References listed on IDEAS

    as
    1. Filomena Pietrantonio & Antonio Vinci & Francesco Rosiello & Elena Alessi & Matteo Pascucci & Marianna Rainone & Michela Delli Castelli & Angela Ciamei & Fabrizio Montagnese & Roberto D’Amico & Antone, 2021. "Green Line Hospital-Territory Study: A Single-Blind Randomized Clinical Trial for Evaluation of Technological Challenges of Continuous Wireless Monitoring in Internal Medicine, Preliminary Results," IJERPH, MDPI, vol. 18(19), pages 1-12, September.
    2. Filomena Pietrantonio & Francesco Rosiello & Elena Alessi & Matteo Pascucci & Marianna Rainone & Enrica Cipriano & Alessandra Di Berardino & Antonio Vinci & Matteo Ruggeri & Serafino Ricci, 2021. "Burden of COVID-19 on Italian Internal Medicine Wards: Delphi, SWOT, and Performance Analysis after Two Pandemic Waves in the Local Health Authority “Roma 6” Hospital Structures," IJERPH, MDPI, vol. 18(11), pages 1-11, June.
    Full references (including those not matched with items on IDEAS)

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