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Cannabis and Paternal Epigenetic Inheritance

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  • Filomena Mazzeo

    (Dipartimento di Scienze Economiche, Giuridiche, Informatiche e Motorie, Università di Napoli Parthenope, Nola, 80035 Naples, Italy
    Department of Economics, Law, Cybersecurity and Sports Sciences, University of Naples “Parthenope”, Nola, 80133 Naples, Italy)

  • Rosaria Meccariello

    (Dipartimento di Scienze Motorie e del Benessere, Università di Napoli Parthenope, 80133 Napoli, Italy
    Department of Movement Sciences and Wellbeing, University “Parthenope”, 80133 Naples, Italy)

Abstract

Cannabis is the most widely used illicit drug in Western counties and its abuse is particularly high in male adolescents and young adults. Its main psychotropic component, the cannabinoid delta-9-tetrahydrocannabinol (Δ 9 -THC), interferes in the endogenous endocannabinoid system. This signaling system is involved in the control of many biological activities, including the formation of high-quality male gametes. Direct adverse effects of Δ 9 -THC in male reproduction are well known in both animal models and humans. Nevertheless, the possibility of long-term effects due to epigenetic mechanisms has recently been reported. In this review, we summarize the main advances in the field suggesting the need to pay attention to the possible long-term epigenetic risks for the reproductive health of cannabis users and the health of their offspring.

Suggested Citation

  • Filomena Mazzeo & Rosaria Meccariello, 2023. "Cannabis and Paternal Epigenetic Inheritance," IJERPH, MDPI, vol. 20(9), pages 1-14, April.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:9:p:5663-:d:1134091
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    References listed on IDEAS

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    1. Maria Letizia Motti & Rosaria Meccariello, 2019. "Minireview: The Epigenetic Modulation of KISS1 in Reproduction and Cancer," IJERPH, MDPI, vol. 16(14), pages 1-9, July.
    2. Saher Sue Hammoud & David A. Nix & Haiying Zhang & Jahnvi Purwar & Douglas T. Carrell & Bradley R. Cairns, 2009. "Distinctive chromatin in human sperm packages genes for embryo development," Nature, Nature, vol. 460(7254), pages 473-478, July.
    3. Stefania D'Angelo & Rosaria Meccariello, 2021. "Microplastics: A Threat for Male Fertility," IJERPH, MDPI, vol. 18(5), pages 1-11, March.
    4. Stefania D’Angelo & Elena Mele & Federico Di Filippo & Andrea Viggiano & Rosaria Meccariello, 2021. "Sirt1 Activity in the Brain: Simultaneous Effects on Energy Homeostasis and Reproduction," IJERPH, MDPI, vol. 18(3), pages 1-17, January.
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