IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v20y2023i7p5300-d1110122.html
   My bibliography  Save this article

Risk of Lactic Acidosis in Hospitalized Diabetic Patients Prescribed Biguanides in Japan: A Retrospective Total-Population Cohort Study

Author

Listed:
  • Takako Mohri

    (Department of Diabetes and Endocrinology, Nara Medical University Hospital, Nara 634-8522, Japan)

  • Sawako Okamoto

    (Department of Public Health, Health Management and Policy, Nara Medical University, Nara 634-8521, Japan
    Education Development Center, Nara Medical University, Nara 634-8521, Japan)

  • Yuichi Nishioka

    (Department of Public Health, Health Management and Policy, Nara Medical University, Nara 634-8521, Japan)

  • Tomoya Myojin

    (Department of Public Health, Health Management and Policy, Nara Medical University, Nara 634-8521, Japan)

  • Shinichiro Kubo

    (Department of Public Health, Health Management and Policy, Nara Medical University, Nara 634-8521, Japan)

  • Tsuneyuki Higashino

    (Healthcare and Wellness Division, Mitsubishi Research Institute Inc., Tokyo 100-8141, Japan)

  • Sadanori Okada

    (Department of Diabetes and Endocrinology, Nara Medical University Hospital, Nara 634-8522, Japan)

  • Yasuhiro Akai

    (Department of Community-Based Medicine, Nara Medical University, Nara 634-8521, Japan)

  • Tatsuya Noda

    (Department of Public Health, Health Management and Policy, Nara Medical University, Nara 634-8521, Japan)

  • Hitoshi Ishii

    (Department of Doctor-Patient Relationships, Nara Medical University, Nara 634-8521, Japan)

  • Tomoaki Imamura

    (Department of Public Health, Health Management and Policy, Nara Medical University, Nara 634-8521, Japan)

Abstract

Patient data from the National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB) are used to assess the effect of biguanide administration on rates of lactic acidosis (LA) in hospitalized diabetes mellitus (DM) patients. In this retrospective cohort study (from April 2013 to March 2016), we compare DM inpatients prescribed biguanides to DM inpatients who were not prescribed biguanides to quantify the association between biguanides and incidence of LA. In total, 8,111,848 DM patient records are retrieved from the NDB. Of the 528,768 inpatients prescribed biguanides, 782 develop LA. Of the 1,967,982 inpatients not prescribed biguanides, 1310 develop LA. The rate ratio of inpatients who develop LA and are administered biguanides to those who developed LA without receiving biguanides is 1.44 (95% CI, 1.32–1.58). Incidence rates and rate ratios for both sexes are elevated in the group prescribed biguanides for patients aged 70 years and older, markedly in those 80 years and older: 40.12 and 6.31 (95% CI, 4.75–8.39), respectively, for men and 34.96 and 5.40 (95% CI, 3.91–7.46), respectively, for women. Biguanides should be used conservatively in patients older than 70 years, particularly for those with comorbidities, and with caution in patients 80 years and older.

Suggested Citation

  • Takako Mohri & Sawako Okamoto & Yuichi Nishioka & Tomoya Myojin & Shinichiro Kubo & Tsuneyuki Higashino & Sadanori Okada & Yasuhiro Akai & Tatsuya Noda & Hitoshi Ishii & Tomoaki Imamura, 2023. "Risk of Lactic Acidosis in Hospitalized Diabetic Patients Prescribed Biguanides in Japan: A Retrospective Total-Population Cohort Study," IJERPH, MDPI, vol. 20(7), pages 1-12, March.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:7:p:5300-:d:1110122
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/20/7/5300/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/20/7/5300/
    Download Restriction: no
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:20:y:2023:i:7:p:5300-:d:1110122. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.