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Distinct Predictors of Clinical Response after Repetitive Transcranial Magnetic Stimulation between Bipolar and Unipolar Disorders

Author

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  • Aurélie Lacroix

    (Unité de Recherche et d’Innovation, Centre Hospitalier Esquirol, 87025 Limoges, France
    INSERM, U1094 Institut d’Epidémiologie et de Neurologie Tropicale, Université de Limoges, CHU Limoges, IRD U270, GEIST, 87000 Limoges, France)

  • Aude Paquet

    (Unité de Recherche et d’Innovation, Centre Hospitalier Esquirol, 87025 Limoges, France
    INSERM, U1094 Institut d’Epidémiologie et de Neurologie Tropicale, Université de Limoges, CHU Limoges, IRD U270, GEIST, 87000 Limoges, France
    Centre de Recherche en Epidémiologie et Santé des Populations, U1018 INSERM, Paris-Saclay Université, UVSQ, 94800 Villejuif, France)

  • Mireille Okassa

    (Unité de Recherche et d’Innovation, Centre Hospitalier Esquirol, 87025 Limoges, France)

  • Théodore Vinais

    (Unité de Recherche et d’Innovation, Centre Hospitalier Esquirol, 87025 Limoges, France)

  • Marilyne Lannaud

    (Unité de Recherche et d’Innovation, Centre Hospitalier Esquirol, 87025 Limoges, France)

  • Brigitte Plansont

    (Unité de Recherche et d’Innovation, Centre Hospitalier Esquirol, 87025 Limoges, France)

  • Alexandre Buisson

    (Unité de Recherche et d’Innovation, Centre Hospitalier Esquirol, 87025 Limoges, France)

  • Sandrine Guignandon

    (Unité de Recherche et d’Innovation, Centre Hospitalier Esquirol, 87025 Limoges, France)

  • Dominique Malauzat

    (Unité de Recherche et d’Innovation, Centre Hospitalier Esquirol, 87025 Limoges, France)

  • Murielle Girard

    (Unité de Recherche et d’Innovation, Centre Hospitalier Esquirol, 87025 Limoges, France
    INSERM, U1094 Institut d’Epidémiologie et de Neurologie Tropicale, Université de Limoges, CHU Limoges, IRD U270, GEIST, 87000 Limoges, France)

  • Benjamin Calvet

    (Unité de Recherche et d’Innovation, Centre Hospitalier Esquirol, 87025 Limoges, France
    INSERM, U1094 Institut d’Epidémiologie et de Neurologie Tropicale, Université de Limoges, CHU Limoges, IRD U270, GEIST, 87000 Limoges, France)

Abstract

Background: Repetitive transcranial magnetic stimulation (rTMS) has been shown to be therapeutically effective for patients suffering from drug-resistant depression. The distinction between bipolar and unipolar disorders would be of great interests to better adapt their respective treatments. Methods: We aimed to identify the factors predicting clinical improvement at one month (M1) after the start of rTMS treatment for each diagnosis, which was preceded by a comparison of the patients’ clinical conditions. We used the data collected and the method employed in a previous publication on 291 patients. Results: Although the bipolar group had fewer responders, these patients seemed to better maintain their post-rTMS improvement on anxiety and perception of the severity of their illness than those in the unipolar group. For the bipolar group, young age coupled with low number of medications and high fatigue was shown to be the best combination for predicting improvement at M1. The duration of current depressive episode, which was previously demonstrated for whole group, combined with being attached was shown to favor clinical improvement among the patients in unipolar group. Conclusion: We were able to define a combination of specific factors related to each diagnosis for predicting the patients’ clinical response. This could be extremely useful to predict the efficacy of rTMS during routine clinical practice in neuromodulation services.

Suggested Citation

  • Aurélie Lacroix & Aude Paquet & Mireille Okassa & Théodore Vinais & Marilyne Lannaud & Brigitte Plansont & Alexandre Buisson & Sandrine Guignandon & Dominique Malauzat & Murielle Girard & Benjamin Cal, 2023. "Distinct Predictors of Clinical Response after Repetitive Transcranial Magnetic Stimulation between Bipolar and Unipolar Disorders," IJERPH, MDPI, vol. 20(7), pages 1-10, March.
  • Handle: RePEc:gam:jijerp:v:20:y:2023:i:7:p:5276-:d:1108733
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