IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v20y2023i6p4951-d1094319.html
   My bibliography  Save this article

The Effect of Serum Leptin Concentration and Leptin Receptor Expression on Colorectal Cancer

Author

Listed:
  • Sylwia Chludzińska-Kasperuk

    (Biobank, Medical University of Bialystok, 15-269 Bialystok, Poland
    Department of Primary Health Care, Medical University of Bialystok, 15-054 Bialystok, Poland)

  • Jolanta Lewko

    (Department of Primary Health Care, Medical University of Bialystok, 15-054 Bialystok, Poland)

  • Regina Sierżantowicz

    (Department of Surgical Nursing, Medical University of Bialystok, 15-274 Bialystok, Poland)

  • Elżbieta Krajewska-Kułak

    (Department of Integrated Medical Care, Medical University of Bialystok, 15-089 Bialystok, Poland)

  • Joanna Reszeć-Giełażyn

    (Department of Medical Pathomorphology, Medical University of Bialystok, 15-269 Bialystok, Poland)

Abstract

Introduction: The level of leptin in the blood shows a positive, strong correlation with the mass of adipose tissue. Being overweight and having metabolic disorders increase the risk of developing colorectal cancer. Aim of the Paper: The aim of the study was to assess the concentration of leptin in the blood serum as well as the expression of the leptin receptor in colorectal cancer cells. In addition, the effect of serum leptin concentration and leptin receptor expression on clinical and pathological parameters such as BMI, obesity, TNM, and tumor size was assessed. Methods: The study included 61 patients diagnosed with colorectal cancer and treated with surgery. Results: Strong leptin receptor expression and the prevalence of overweight and obesity are factors influencing the occurrence of excessive leptin concentrations. Conclusion: Leptin may be involved in the development and progression of colorectal cancer. More research is needed to better elucidate the role of leptin in the development and progression of the disease.

Suggested Citation

  • Sylwia Chludzińska-Kasperuk & Jolanta Lewko & Regina Sierżantowicz & Elżbieta Krajewska-Kułak & Joanna Reszeć-Giełażyn, 2023. "The Effect of Serum Leptin Concentration and Leptin Receptor Expression on Colorectal Cancer," IJERPH, MDPI, vol. 20(6), pages 1-13, March.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:6:p:4951-:d:1094319
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/20/6/4951/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/20/6/4951/
    Download Restriction: no
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:20:y:2023:i:6:p:4951-:d:1094319. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.