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Association between Glutathione S-Transferases Gene Variants and COVID-19 Severity in Previously Vaccinated and Unvaccinated Polish Patients with Confirmed SARS-CoV-2 Infection

Author

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  • Katarzyna Orlewska

    (Collegium Medicum, Jan Kochanowski University, 25-317 Kielce, Poland)

  • Justyna Klusek

    (Collegium Medicum, Jan Kochanowski University, 25-317 Kielce, Poland)

  • Dorota Zarębska-Michaluk

    (Collegium Medicum, Jan Kochanowski University, 25-317 Kielce, Poland)

  • Kamila Kocańda

    (Collegium Medicum, Jan Kochanowski University, 25-317 Kielce, Poland)

  • Ruslan Oblap

    (Collegium Medicum, Jan Kochanowski University, 25-317 Kielce, Poland)

  • Anna Cedro

    (Collegium Medicum, Jan Kochanowski University, 25-317 Kielce, Poland)

  • Bartosz Witczak

    (Collegium Medicum, Jan Kochanowski University, 25-317 Kielce, Poland)

  • Jolanta Klusek

    (Institute of Biology, Jan Kochanowski University, 25-406 Kielce, Poland)

  • Andrzej Śliwczyński

    (Faculty of Medicine, Lazarski University, 02-662 Warsaw, Poland
    Central Clinical Hospital of the Ministry of Interior and Administration, 02-507 Warsaw, Poland)

  • Ewa Orlewska

    (Collegium Medicum, Jan Kochanowski University, 25-317 Kielce, Poland)

Abstract

As the outcome of COVID-19 is associated with oxidative stress, it is highly probable that polymorphisms of genes related to oxidative stress were associated with susceptibility and severity of COVID-19. The aim of the study was to assess the association of glutathione S-transferases (GSTs) gene polymorphisms with COVID-19 severity in previously vaccinated and unvaccinated Polish patients with confirmed SARS-CoV-2 infection. A total of 92 not vaccinated and 84 vaccinated patients hospitalized due to COVID-19 were included. The WHO COVID-19 Clinical Progression Scale was used to assess COVID-19 severity. GSTs genetic polymorphisms were assessed by appropriate PCR methods. Univariable and multivariable analyses were performed, including logistic regression analysis. GSTP1 Ile/Val genotype was found to be associated with a higher risk of developing a severe form of the disease in the population of vaccinated patients with COVID-19 (OR: 2.75; p = 0.0398). No significant association was observed for any of the assessed GST genotypes with COVID-19 disease severity in unvaccinated patients with COVID-19. In this group of patients, BMI > 25 and serum glucose level > 99 mg% statistically significantly increased the odds towards more severe COVID-19. Our results may contribute to further understanding of risk factors of severe COVID-19 and selecting patients in need of strategies focusing on oxidative stress.

Suggested Citation

  • Katarzyna Orlewska & Justyna Klusek & Dorota Zarębska-Michaluk & Kamila Kocańda & Ruslan Oblap & Anna Cedro & Bartosz Witczak & Jolanta Klusek & Andrzej Śliwczyński & Ewa Orlewska, 2023. "Association between Glutathione S-Transferases Gene Variants and COVID-19 Severity in Previously Vaccinated and Unvaccinated Polish Patients with Confirmed SARS-CoV-2 Infection," IJERPH, MDPI, vol. 20(4), pages 1-11, February.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:4:p:3752-:d:1074644
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    References listed on IDEAS

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    1. Erola Pairo-Castineira & Sara Clohisey & Lucija Klaric & Andrew D. Bretherick & Konrad Rawlik & Dorota Pasko & Susan Walker & Nick Parkinson & Max Head Fourman & Clark D. Russell & James Furniss & Ann, 2021. "Genetic mechanisms of critical illness in COVID-19," Nature, Nature, vol. 591(7848), pages 92-98, March.
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