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Metabolic and Inflammatory Response in Post-Traumatic Stress Disorder (PTSD): A Systematic Review on Peripheral Neuroimmune Biomarkers

Author

Listed:
  • Valerio Dell’Oste

    (Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy
    Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy)

  • Sara Fantasia

    (Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy)

  • Davide Gravina

    (Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy)

  • Lionella Palego

    (Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy)

  • Laura Betti

    (Department of Pharmacy, University of Pisa, 56126 Pisa, Italy)

  • Liliana Dell’Osso

    (Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy)

  • Gino Giannaccini

    (Department of Pharmacy, University of Pisa, 56126 Pisa, Italy)

  • Claudia Carmassi

    (Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy)

Abstract

Several heterogeneous pathophysiology pathways have been hypothesized for being involved in the onset and course of Post-Traumatic Stress Disorder (PTSD). This systematic review aims to summarize the current evidence on the role of inflammation and immunological dysregulations in PTSD, investigating possible peripheral biomarkers linked to the neuroimmune response to stress. A total of 44 studies on the dysregulated inflammatory and metabolic response in subjects with PTSD with respect to controls were included. Eligibility criteria included full-text publications in the English language, human adult samples, studies involving both subjects with a clinical diagnosis of PTSD and a healthy control group. The research was focused on specific blood neuroimmune biomarkers, namely IL-1β, TNF-α, IL-6 and INF-γ, as well as on the potential harmful role of reduced antioxidant activity (involving catalase, superoxide dismutase and glutathione peroxidase). The possible role of the inflammatory-altered tryptophan metabolism was also explored. The results showed conflicting data on the role of pro-inflammatory cytokines in individuals with PTSD, and a lack of study regarding the other mediators investigated. The present research suggests the need for further studies in human samples to clarify the role of inflammation in the pathogenesis of PTSD, to define potential peripheral biomarkers.

Suggested Citation

  • Valerio Dell’Oste & Sara Fantasia & Davide Gravina & Lionella Palego & Laura Betti & Liliana Dell’Osso & Gino Giannaccini & Claudia Carmassi, 2023. "Metabolic and Inflammatory Response in Post-Traumatic Stress Disorder (PTSD): A Systematic Review on Peripheral Neuroimmune Biomarkers," IJERPH, MDPI, vol. 20(4), pages 1-16, February.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:4:p:2937-:d:1061344
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