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One-Hour Post-Load Plasma Glucose and Altered Glucometabolic Profile in Youths with Overweight or Obesity

Author

Listed:
  • Procolo Di Bonito

    (Department of Internal Medicine, “S. Maria delle Grazie” Hospital, 80078 Pozzuoli, Italy
    These authors contributed equally to this work.)

  • Giuliana Valerio

    (Department of Movement Sciences and Wellbeing, University of Napoli “Parthenope”, 80133 Napoli, Italy
    These authors contributed equally to this work.)

  • Maria Rosaria Licenziati

    (Neuro-Endocrine Diseases and Obesity Unit, Department of Neurosciences, Santobono-Pausilipon Children’s Hospital, 80139 Napoli, Italy)

  • Domenico Corica

    (Department of Human Pathology in Adulthood and Childhood, University of Messina, 98125 Messina, Italy)

  • Malgorzata Wasniewska

    (Department of Human Pathology in Adulthood and Childhood, University of Messina, 98125 Messina, Italy)

  • Anna Di Sessa

    (Department of Woman, Child and of General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Napoli, Italy)

  • Emanuele Miraglia del Giudice

    (Department of Woman, Child and of General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Napoli, Italy)

  • Anita Morandi

    (Department of Surgery, Dentistry, Pediatrics and Gynecology, Section of Pediatric Diabetes and Metabolism, University and Azienda Ospedaliera Universitaria Integrata of Verona, 37126 Verona, Italy)

  • Claudio Maffeis

    (Department of Surgery, Dentistry, Pediatrics and Gynecology, Section of Pediatric Diabetes and Metabolism, University and Azienda Ospedaliera Universitaria Integrata of Verona, 37126 Verona, Italy)

  • Enza Mozzillo

    (Section of Pediatrics, Department of Translational Medical Science, Regional Center of Pediatric Diabetes, University of Naples “Federico II”, 80131 Napoli, Italy)

  • Valeria Calcaterra

    (Pediatric Department, “V. Buzzi” Children’s Hospital, 20154 Milano, Italy
    Department of Internal Medicine, University of Pavia, 27100 Pavia, Italy)

  • Francesca Franco

    (Pediatric Department, Azienda Sanitaria Universitaria Friuli Centrale, Hospital of Udine, 33100 Udine, Italy)

  • Giulio Maltoni

    (Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy)

  • Maria Felicia Faienza

    (Department of Precision and Regenerative Medicine and Ionian Area, University of Bari “Aldo Moro”, 70121 Bari, Italy)

Abstract

In youths, two cut-offs (133 and 155 mg/dL) have been proposed to identify high glucose levels at the 1 h (G 60 ) mark during an oral glucose tolerance test (OGTT). We evaluated which cut-off was more closely associated with isolated impaired glucose tolerance (IGT) and cardiometabolic risk (CMR) in 1199 youth with overweight/obesity (OW/OB) and normal fasting glucose and/or HbA1c. The disposition index (DI) was available in 724 youths. The sample was divided by two cut-offs of G 60 : <133 mg/dL (n = 853) and ≥133 mg/dL (n = 346), or G 60 < 155 mg/dL (n = 1050) and ≥155 mg/dL (n = 149). Independent of the cut-off, youths with high levels of G 60 showed higher levels of G 120 , insulin resistance (IR), triglycerides to HDL ratio (TG/HDL), alanine aminotransferase (ALT), and lower insulin sensitivity (IS) and DI than youths with lower levels of G 60 . The percentage of youths showing IGT, IR, low IS, high TG/HDL ratio, high ALT, and low DI was 50% higher in the G 60 ≥ 133 mg/dL group than in the G 60 ≥ 155 mg/dL one. In youths with OW/OB and IGT, a cut-off of G 60 ≥ 133 mg/dL is more useful than G 60 ≥ 155 mg/dL to identify those at high risk of IGT and altered CMR profile.

Suggested Citation

  • Procolo Di Bonito & Giuliana Valerio & Maria Rosaria Licenziati & Domenico Corica & Malgorzata Wasniewska & Anna Di Sessa & Emanuele Miraglia del Giudice & Anita Morandi & Claudio Maffeis & Enza Mozzi, 2023. "One-Hour Post-Load Plasma Glucose and Altered Glucometabolic Profile in Youths with Overweight or Obesity," IJERPH, MDPI, vol. 20(11), pages 1-11, May.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:11:p:5961-:d:1156519
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