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Oestrogenic Activity in Girls with Signs of Precocious Puberty as Exposure Biomarker to Endocrine Disrupting Chemicals: A Pilot Study

Author

Listed:
  • Marta Gea

    (Department of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy)

  • Anna Toso

    (Department of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy
    Institut de Recherche en Cancérologie de Montpellier (IRCM), Inserm U1194, Institut régional du Cancer de Montpellier (ICM), Université Montpellier, 34090 Montpellier, France)

  • Giuseppe Nicolò Bentivegna

    (Department of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy)

  • Raffaele Buganza

    (Unit of Pediatric Endocrinology, Department of Public Health and Pediatrics, Regina Margherita Children Hospital, University of Turin, 10126 Turin, Italy)

  • Enrica Abrigo

    (Unit of Pediatric Endocrinology, Department of Public Health and Pediatrics, Regina Margherita Children Hospital, University of Turin, 10126 Turin, Italy)

  • Luisa De Sanctis

    (Department of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy
    Unit of Pediatric Endocrinology, Department of Public Health and Pediatrics, Regina Margherita Children Hospital, University of Turin, 10126 Turin, Italy)

  • Tiziana Schilirò

    (Department of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy)

Abstract

The relationship between endocrine disrupting chemical (EDC) exposure and Precocious Puberty (PP) was investigated in this pilot study, involving girls with signs of PP (P) and pre-pubertal girls (C). Risk factors for PP were assessed through questionnaires, while 17β-oestradiol (E2) levels and oestrogenic activity were quantified on sera. The oestrogenic activity, expressed as E2 equivalent concentration (EEQ), was applied as EDC exposure biomarker. Questionnaires showed a low EDC knowledge, a high EDC exposure, and a potential relationship between some habits at risk for EDC exposure and PP. EEQs were similar between C and P; however, they were significantly higher in girls living in an urban environment than in girls living in a rural environment, suggesting a potential higher EDC exposure in cities. The results of this pilot study highlighted the need to raise awareness on EDCs and can be considered a starting point to clarify the relationship between EDC exposure and PP.

Suggested Citation

  • Marta Gea & Anna Toso & Giuseppe Nicolò Bentivegna & Raffaele Buganza & Enrica Abrigo & Luisa De Sanctis & Tiziana Schilirò, 2022. "Oestrogenic Activity in Girls with Signs of Precocious Puberty as Exposure Biomarker to Endocrine Disrupting Chemicals: A Pilot Study," IJERPH, MDPI, vol. 20(1), pages 1-18, December.
    • Handle: RePEc:gam:jijerp:v:20:y:2022:i:1:p:14-:d:1008840
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