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Peri-Implant Surgical Treatment Downregulates the Expression of sTREM-1 and MMP-8 in Patients with Peri-Implantitis: A Prospective Study

Author

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  • Glaucia Schuindt Teixeira Neves

    (Department of Prosthodontics, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro 20551-030, Brazil
    Department of Endodontics, School of Dentistry, University of Texas, Houston, TX 77054, USA
    These authors contributed equally to this work.)

  • Gayathiri Elangovan

    (School of Medicine and Dentistry, Griffith University, Gold Coast, Queensland 4222, Australia
    These authors contributed equally to this work.)

  • Mayla Kezy Silva Teixeira

    (Department of Prosthodontics, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro 20551-030, Brazil)

  • João Martins de Mello-Neto

    (School of Medicine and Dentistry, Griffith University, Gold Coast, Queensland 4222, Australia)

  • Santosh Kumar Tadakamadla

    (School of Medicine and Dentistry, Griffith University, Gold Coast, Queensland 4222, Australia
    Menzies Health Institute Queensland, Queensland 4222, Australia)

  • Eduardo José Veras Lourenço

    (Department of Prosthodontics, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro 20551-030, Brazil)

  • Daniel Moraes Telles

    (Department of Prosthodontics, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro 20551-030, Brazil)

  • Carlos Marcelo Figueredo

    (School of Medicine and Dentistry, Griffith University, Gold Coast, Queensland 4222, Australia
    Department of Periodontology, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro 20551-030, Brazil)

Abstract

sTREM-1 and its ligand PGLYRP1 play an essential role in the inflammatory process around teeth and implants. In this study, we aimed to evaluate the impact of peri-implant treatment on the salivary levels of the sTREM-1/PGLYRP-1/MMP-8 axis after 3 months. A total of 42 participants (with a mean age of 61 years old ± 7.3) were enrolled in this longitudinal study, 24 having peri-implant mucositis (MU) and 18 having peri-implantitis (PI). Clinical peri-implant parameters, such as probing pocket depth (PPD), % of plaque, and bleeding on probing (BOP), and the whole unstimulated saliva samples were evaluated at baseline and 3 months after treatment. The MU group received nonsurgical peri-implant treatment, while the PI group received open-flap procedures. The levels of sTREM-1, PGLYRP-1, MMP-8, and TIMP-1 were analyzed using enzyme-linked immunosorbent assays. BOP, plaque levels, and PPD significantly reduced after treatment in both groups. A significant decrease in the salivary levels of sTREM-1, MMP-8, and TIMP-1 in the PI group and PGLYRP1 and TIMP-1 in the MU group were observed. Salivary levels of sTREM-1 were significantly reduced in patients with PI but not with MU. Additionally, peri-implant treatment had a significantly higher impact on MMP-8 reduction in patients with PI than in those with MU.

Suggested Citation

  • Glaucia Schuindt Teixeira Neves & Gayathiri Elangovan & Mayla Kezy Silva Teixeira & João Martins de Mello-Neto & Santosh Kumar Tadakamadla & Eduardo José Veras Lourenço & Daniel Moraes Telles & Carlos, 2022. "Peri-Implant Surgical Treatment Downregulates the Expression of sTREM-1 and MMP-8 in Patients with Peri-Implantitis: A Prospective Study," IJERPH, MDPI, vol. 19(6), pages 1-12, March.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:6:p:3627-:d:774345
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