IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i6p3531-d772602.html
   My bibliography  Save this article

A Six-Year Gynecological Follow-Up of Immunosuppressed Women with a High-Risk Human Papillomavirus Infection

Author

Listed:
  • Aleksandra Wielgos

    (Department of Dermatology, Medical University of Warsaw, 02-008 Warsaw, Poland)

  • Bronisława Pietrzak

    (1st Department of Obstetrics and Gynecology, Medical University of Warsaw, 02-115 Warsaw, Poland)

  • Barbara Suchonska

    (1st Department of Obstetrics and Gynecology, Medical University of Warsaw, 02-115 Warsaw, Poland)

  • Mariusz Sikora

    (National Institute of Geriatrics, Rheumatology and Rehabilitation, 02-006 Warsaw, Poland)

  • Lidia Rudnicka

    (Department of Dermatology, Medical University of Warsaw, 02-008 Warsaw, Poland)

  • Miroslaw Wielgos

    (1st Department of Obstetrics and Gynecology, Medical University of Warsaw, 02-115 Warsaw, Poland)

Abstract

Immunocompromised women are at an increased risk of developing malignancies, especially those that are viral-induced, such as invasive cervical cancer caused by the human papillomavirus (HPV). The aim of the study was to describe gynecological follow-up of women undergoing chronic immunosuppressive therapy for various reasons (e.g., kidney/liver transplant, systemic lupus erythematosus), diagnosed with a high-risk HPV (hrHPV) infection based on a self-sampling test. Twenty-six hrHPV-positive women were invited to take part in a gynecological follow-up, including a visual assessment of the anogenital region, two-handed gynecological examination, and cervical cytology as well as a colposcopy and cervical biopsy when necessary. Four women declined taking part in the study. Over six years of observation, low-grade squamous intraepithelial lesions (LSIL) were detected at least once in 7/22 women (31.8%), and a cervical intraepithelial lesion 1 (CIN 1) histopathologic result was obtained five times in 3/22 women. No cases of high-grade squamous intraepithelial lesions, CIN 2/3, or invasive cervical cancers were observed. Loop electrosurgical excision procedure (LEEP) was performed in three patients. As immunocompromised women are prone to persistent hrHPV infections, they should be under strict gynecological supervision because only vigilant surveillance enables fast detection and treatment of early dysplasia and, therefore, provides a chance for the reduction of the cervical cancer burden.

Suggested Citation

  • Aleksandra Wielgos & Bronisława Pietrzak & Barbara Suchonska & Mariusz Sikora & Lidia Rudnicka & Miroslaw Wielgos, 2022. "A Six-Year Gynecological Follow-Up of Immunosuppressed Women with a High-Risk Human Papillomavirus Infection," IJERPH, MDPI, vol. 19(6), pages 1-9, March.
  • Handle: RePEc:gam:jijerp:v:19:y:2022:i:6:p:3531-:d:772602
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/6/3531/pdf
    Download Restriction: no

    File URL: https://www.mdpi.com/1660-4601/19/6/3531/
    Download Restriction: no
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:6:p:3531-:d:772602. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.