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A Systematic Review of the Effect of Centella asiatica on Wound Healing

Author

Listed:
  • Elena Arribas-López

    (School of Science, Medway Campus, University of Greenwich, Central Ave, Gillingham, Chatham Maritime, Kent ME4 4TB, UK)

  • Nazanin Zand

    (School of Science, Medway Campus, University of Greenwich, Central Ave, Gillingham, Chatham Maritime, Kent ME4 4TB, UK)

  • Omorogieva Ojo

    (School of Health Sciences, Avery Hill Campus, University of Greenwich, Avery Hill Road, London SE9 2UG, UK)

  • Martin John Snowden

    (School of Science, Medway Campus, University of Greenwich, Central Ave, Gillingham, Chatham Maritime, Kent ME4 4TB, UK)

  • Tony Kochhar

    (HCA London Bridge Hospital, Tooley Street, London SE1 2PR, UK)

Abstract

Background: Under metabolic stress conditions, there is a higher demand for nutrients which needs to be met. This is to reduce the risk of delay in wound healing which could lead to chronic wound. Aim: This is a systematic review of the effect of Centella asiatica on wound healing. C. asiatica is a traditional medicinal plant used due to its antimicrobial, antioxidant, anti-inflammatory, neuroprotective, and wound healing properties. Methods: PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines were followed for the systematic review and four electronic databases were used. Results: Four clinical trials met the inclusion criteria. The following distinct areas were identified under C. asiatica : wound contraction and granulation; healing/bleeding time and re-epithelialization; VAS (visual analogue scale) scores; skin erythema and wound appearance. Conclusions: C. asiatica might enhance wound healing resulting from improved angiogenesis. This might occur due to its stimulating effect on collagen I, Fibroblast Growth Factor (FGF) and Vascular Endothelial Growth Factor (VEGF) production. Besides, C. asiatica has shown an anti-inflammatory effect observed by the reduction in Interleukin-1β (IL-1β), Interleukin-6 (IL-6) and Tumour Necrosis Factor α (TNFα), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), and lipoxygenase (LOX) activity. Delivery systems such as nanoencapsulation could be used to increase C. asiatica bioavailability. Nevertheless, more studies are needed in order to perform a meta-analysis and ascertain the effects of C. asiatica on wound healing and its different parameters.

Suggested Citation

  • Elena Arribas-López & Nazanin Zand & Omorogieva Ojo & Martin John Snowden & Tony Kochhar, 2022. "A Systematic Review of the Effect of Centella asiatica on Wound Healing," IJERPH, MDPI, vol. 19(6), pages 1-13, March.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:6:p:3266-:d:768150
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    Cited by:

    1. Damasus Riyanto & Meksy Dianawati & Sutardi & Heru Susanto & Nugroho Adi Sasongko & Niluh Putu Sri Ratmini & Popi Rejekiningrum & Yustisia & Helena Lina Susilawati & Hano Hanafi & Sodiq Jauhari & Mart, 2022. "The Effect of P 2 O 5 Fertilizer, Zeolite, and Volcanic Soil Media from Different Altitudes on the Soil Mineral, Growth, Yield, and Asiaticoside Content of Centella asiatica L," Sustainability, MDPI, vol. 14(22), pages 1-16, November.

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