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How Comorbidities Affect Hospitalization from Influenza in the Pediatric Population

Author

Listed:
  • Sophia C. Mylonakis

    (Infectious Diseases Division, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA)

  • Evangelia K. Mylona

    (Infectious Diseases Division, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA)

  • Markos Kalligeros

    (Infectious Diseases Division, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    Department of Medicine, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA)

  • Fadi Shehadeh

    (Infectious Diseases Division, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    School of Electrical and Computer Engineering, National Technical University of Athens, 15780 Athens, Greece)

  • Philip A. Chan

    (Infectious Diseases Division, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    Division of Preparedness, Response, Infectious Disease, and Emergency Medical Services, Rhode Island Department of Health, Providence, RI 02908, USA)

  • Eleftherios Mylonakis

    (Infectious Diseases Division, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA)

Abstract

Influenza is a contagious respiratory illness and can lead to hospitalization and even death. Understanding how comorbidities affect the severity of influenza can help clinical management. The aim of this study is to offer more information about comorbidities that might be associated with the severity of influenza in children. We used a statewide network in Rhode Island, USA, to extract data for laboratory-confirmed influenza cases among children 19 years old or younger. We identified 1169 lab-confirmed influenza cases. The most common comorbidities were asthma (17.1%), neurodevelopmental disorders (10.3%), gastrointestinal disorders (7.6%), atopic dermatitis (7%), and endocrine and metabolic diseases (6.8%). Interestingly, 80.8% (63 out of 78) of children who had an influenza-related hospital admission had at least one comorbidity, and among hospitalized children with influenza, the most common comorbidities were neurological diseases (28.2%, 22/78), gastrointestinal disorders (25.6%, 20/78), endocrine and metabolic diseases (24.4%, 19/78), and neurodevelopmental disorders (23.1%, 18/78). Children with endocrine or metabolic diseases were 8.23 times more likely to be admitted to the hospital, and children with neurological disorders were 6.35 times more likely to be admitted (OR: 8.23, 95% CI: 4.42–15.32 and OR: 6.35, 95% CI: 3.60–11.24, respectively). In summary, we identified specific comorbidities associated with influenza hospitalization and length of hospital stay, and these groups should be prioritized for public health interventions.

Suggested Citation

  • Sophia C. Mylonakis & Evangelia K. Mylona & Markos Kalligeros & Fadi Shehadeh & Philip A. Chan & Eleftherios Mylonakis, 2022. "How Comorbidities Affect Hospitalization from Influenza in the Pediatric Population," IJERPH, MDPI, vol. 19(5), pages 1-9, February.
  • Handle: RePEc:gam:jijerp:v:19:y:2022:i:5:p:2811-:d:760516
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    Cited by:

    1. Ioanna Avakian & Katerina Dadouli & Lemonia Anagnostopoulos & Konstantinos Fotiadis & Athanasios Lianos & Paraskevi Mina & Christos Hadjichristodoulou & Varvara A. Mouchtouri, 2023. "Nationwide Survey on Seasonal Influenza Vaccination among Health Care Workers during the COVID-19 Pandemic in Greece: Determinants, Barriers and Peculiarities," IJERPH, MDPI, vol. 20(13), pages 1-13, June.

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