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The Pattern of Hemoglobin A1C Trajectories and Risk of Herpes Zoster Infection: A Follow-Up Study

Author

Listed:
  • Bo-Lin Pan

    (Department of Family Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan)

  • Chia-Pei Chou

    (Department of Family Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan)

  • Kun-Siang Huang

    (Department of Family Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan)

  • Pin-Jie Bin

    (Department of Family Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan)

  • Kuei-Hau Luo

    (Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan)

  • Hung-Yi Chuang

    (Department of Community Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan
    Ph.D. Program in Environmental and Occupational Medicine, Research Center for Environmental Medicine, Department of Public Health and Environmental Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan)

Abstract

To investigate the risks of herpes zoster (HZ) infection among heterogeneous HbA1C trajectories of patients with newly diagnosed type 2 diabetes, this cohort study used data from the Chang Gung Research Database (CGRD), from the 10-year period of 1 January 2007 to 31 December 2017. We applied group-based trajectory modeling (GBTM) to identify the patterns of HbA1C trajectories, and multiple Cox proportional hazards regressions were used to estimate the hazard ratio (HR) for the risk of HZ infection with adjustment of age, sex, and comorbidities. This study enrolled 121,999 subjects to perform the analysis. The GBTM identified four HbA1C trajectories: ‘good control’ (58.4%), ‘high decreasing’ (8.9%), ‘moderate control’ (25.1%), and ‘poor control’ (7.6%) with the mean HbA1C of 6.7% (50 mmol/mol), 7.9% (63 mmol/mol), 8.4% (68 mmol/mol), and 10.7% (93 mmol/mol) respectively. The risk of HZ was significantly higher in the poor control with an HR = 1.44 (95% CI 1.26–1.64) after adjustment for confounders and comorbidities. The risk of HZ infection for the high decreasing group (initially poor then rapidly reaching optimal control) was nonsignificant compared to the good control group. In conclusion, the patients with poor glycemic control (mean HbA1C = 10.7%) had the highest risk of HZ infection. The patients with initial hyperglycemia then reaching optimal control could have a lower risk of HZ infection.

Suggested Citation

  • Bo-Lin Pan & Chia-Pei Chou & Kun-Siang Huang & Pin-Jie Bin & Kuei-Hau Luo & Hung-Yi Chuang, 2022. "The Pattern of Hemoglobin A1C Trajectories and Risk of Herpes Zoster Infection: A Follow-Up Study," IJERPH, MDPI, vol. 19(5), pages 1-10, February.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:5:p:2646-:d:757823
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    References listed on IDEAS

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    1. Chi-Chen Ke & Hui-Chin Lai & Ching-Heng Lin & Chih-Jen Hung & Der-Yuan Chen & Wayne H-H Sheu & Ping-Wing Lui, 2016. "Increased Risk of Herpes Zoster in Diabetic Patients Comorbid with Coronary Artery Disease and Microvascular Disorders: A Population-Based Study in Taiwan," PLOS ONE, Public Library of Science, vol. 11(1), pages 1-10, January.
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